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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Childhood obesity elevates blood pressure and total cholesterol independent of physical activity.

OBJECTIVE: To compare the habitual physical activity, blood pressure, total cholesterol levels of obese and non-obese matched children. SUBJECTS: 546 obese children (BMI and sum of skinfolds > or = 90% tile) were matched for gender, race, age, and height (within 2 cm) with non-obese controls for a total sample of 1092 children. MEASUREMENTS: Systolic (BPsys) and diastolic (BPdia) blood pressure by mercury sphygmomanometer, total cholesterol by reflectance photometry, and physical activity by questionnaire. RESULTS: Mean comparisons indicated the obese children, regardless of gender, had higher BPsys (108 +/- 11 vs 104 +/- 10 mm Hg, P = 0.0001), BPdia (70 +/- 9 vs 68 +/- 8 mm Hg, P = 0.002), and greater total cholesterol levels (4.47 +/- 0.80 vs 4.11 +/- 0.75 mmol/L, P = 0.0001) than the non-obese subjects. Self-reported physical activity scores were not significantly different when comparing the obese and non-obese children. Correlations between self-reported activity and cholesterol or blood pressure were all very low and not significant (r < or = 0.06). CONCLUSION: These results suggest that childhood obesity is associated with higher blood pressures and greater circulating cholesterol levels independent of physical activity levels.[1]


  1. Childhood obesity elevates blood pressure and total cholesterol independent of physical activity. McMurray, R.G., Harrel, J.S., Levine, A.A., Gansky, S.A. Int. J. Obes. Relat. Metab. Disord. (1995) [Pubmed]
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