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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Localization of presenilin-1 mRNA in rat brain.

We examined the regional and cellular distribution of presenilin-1 gene expression in the rat brain by in situ hybridization. Microscopic analysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hippocampus, thalamic nuclei and the cerebellar granular layer. The expression of presenilin-1 is mostly neuronal: only a weak hybridization signal was found in the corpus callosum and in the astrocytoma cell lines U373MG and U138MG.[1]


  1. Localization of presenilin-1 mRNA in rat brain. Quarteronet, D., Pradier, L., Czech, C., Delalonde, L., Burgevin, M.C., Doble, A., Petitet, F. Neuroreport (1996) [Pubmed]
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