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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion.

Whereas overexpression of the c-myc gene was found to promote apoptosis in fibroblasts, myeloid, and T cells, physiologic cell death of immature B cell lymphomas correlated with a drop in c-myc expression. Here, the author reviews recent evidence demonstrating that inhibition of c-myc expression activates apoptosis of B cell models of clonal deletion and that rescue from apoptosis by CD40 ligand leads to maintenance of c-Myc levels. A model of differential functional expression of the c-myc gene is discussed.[1]


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