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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The differentiation antigen Ly-6E.1 is expressed in mouse metastatic tumor cell lines.

We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E. 1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.[1]

References

  1. The differentiation antigen Ly-6E.1 is expressed in mouse metastatic tumor cell lines. Cohn, M.A., Kramerov, D., Hulgaard, E.F., Lukanidin, E.M. FEBS Lett. (1997) [Pubmed]
 
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