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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients.

We have measured the metabolic response to sequential administration of propacetamol, metamizol and/or external cooling in 20 febrile patients under sedation and analgesia and during mechanical ventilation. There was no change in temperature (T degree) after propacetamol therapy, whereas after metamizol only a small decrease was noted (from 38.9 (SEM 0.2) to 38.5 (0.3) degrees C; P = 0.02). External cooling produced a significant decrease in T degree (39.1 (0.2) to 37.1 (0.2) degrees C; P < 0.0001) accompanied by a decrease in energy expenditure (EE) (2034 (73) to 1791 (88) kcal day-1; P < 0.004). Heart rate and minute ventilation decreased significantly in parallel. There were no other changes in haemodynamics or pulmonary gas exchanges. We conclude that propacetamol and metamizol did not produce a clinically significant decrease in T degree in febrile ICU patients whereas external cooling decreased both T degree and EE. The parallel decrease in body temperature and EE seemed to be related to opioid administration or sedation, or both.[1]

References

  1. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. Poblete, B., Romand, J.A., Pichard, C., König, P., Suter, P.M. British journal of anaesthesia. (1997) [Pubmed]
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