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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Paternity after bilateral cryptorchidism. A controlled study.

OBJECTIVE: To compare paternity among men with former bilateral cryptorchidism (referred to as the bilateral group) with a group of men with former unilateral cryptorchidism (referred to as the unilateral group) and a control group. DESIGN: Epidemiologic survey of study cohort. SETTING: Large urban pediatric hospital. SUBJECTS: Men with former bilateral and unilateral cryptorchidism who underwent orchiopexy between 1955 and 1971 at the Children's Hospital of Pittsburgh, Pittsburgh, Pa, and a group of control men have been surveyed by questionnaire concerning paternity and factors related to paternity. MAIN OUTCOME MEASURE: Paternity. RESULTS: Among the married men who had bilateral cryptorchidism, 50% had fathered children, compared with 76% in the control group and 74% in the unilateral group. Data were similar when the men who were cohabitating were included with the married men. When men who had married and had attempted paternity were evaluated, 62% of the men in the bilateral group had been able to father children compared with 94% of the control group and 89% of the men in the unilateral group. No relationship was noted between the age of orchiopexy or lifestyle factors and paternity. Paternity among all groups was related to female-related infertility factors and to the presence of varicoceles. CONCLUSIONS: Paternity was compromised after bilateral cryptorchidism when compared with men with former unilateral cryptorchidism and a control group. Among the bilateral group, infertility is about 3.5 times as frequent than the unilateral group and more than 6 times as frequent among the control group. No correlation was found between age of orchiopexy and paternity for either group.[1]


  1. Paternity after bilateral cryptorchidism. A controlled study. Lee, P.A., O'Leary, L.A., Songer, N.J., Coughlin, M.T., Bellinger, M.F., LaPorte, R.E. Archives of pediatrics & adolescent medicine. (1997) [Pubmed]
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