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Disease relevance of Varicocele


Psychiatry related information on Varicocele


High impact information on Varicocele

  • Sperm SHBG levels were lowest in fertile men and highest in patients with untreated varicocele, but these differences were not significant [7].
  • To examine oxidative damage to blood proteins in the spermatic vein and seminal plasma antioxidant capacity of patients with varicocele, 30 young male patients with varicocele (group 1), 25 young male patients with subclinical varicocele (group 2), and 15 normal young males without varicocele (group 3) were recruited in this study [8].
  • Oxidative damage to proteins and decrease of antioxidant capacity in patients with varicocele [8].
  • We therefore evaluated the effects of alpha-human ANP (hANP) administration on testosterone plasma levels in peripheral and internal spermatic venous blood of young men (catheterized for contrast study of varicocele) [9].
  • CONCLUSIONS: Microsurgical repair of varicoceles using isosulfan blue helps in identifying and preserving the lymphatic drainage [10].

Chemical compound and disease context of Varicocele


Biological context of Varicocele


Anatomical context of Varicocele


Gene context of Varicocele


Analytical, diagnostic and therapeutic context of Varicocele


  1. Long-term effects on testicular function of high-dose testosterone treatment for excessively tall stature. Lemcke, B., Zentgraf, J., Behre, H.M., Kliesch, S., Bramswig, J.H., Nieschlag, E. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  2. The varicocele: elevated serotonin and infertility. Caldamone, A.A., Al-Juburi, A., Cockett, A.T. J. Urol. (1980) [Pubmed]
  3. Increased expression of hypoxia-inducible factor-1alpha in the internal spermatic vein of patients with varicocele. Lee, J.D., Jeng, S.Y., Lee, T.H. J. Urol. (2006) [Pubmed]
  4. Serum inhibin B levels and the response to gonadotropin stimulation test in pubertal boys with varicocele. Carrillo, A., Gershbein, A., Glassberg, K.I., Danon, M. J. Urol. (1999) [Pubmed]
  5. Improved semen quality in subfertile males with varicocele-associated oligospermia following treatment with clomiphene citrate. Check, J.H. Fertil. Steril. (1980) [Pubmed]
  6. Low plasma testosterone in varicocele patients with impotence and male infertility. Younes, A.K. Arch. Androl. (2000) [Pubmed]
  7. Human sperm sex hormone-binding globulin isoform: characterization and measurement by time-resolved fluorescence immunoassay. Selva, D.M., Bassas, L., Munell, F., Mata, A., Tekpetey, F., Lewis, J.G., Hammond, G.L. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  8. Oxidative damage to proteins and decrease of antioxidant capacity in patients with varicocele. Chen, S.S., Chang, L.S., Wei, Y.H. Free Radic. Biol. Med. (2001) [Pubmed]
  9. Stimulatory effects of alpha-hANP on testosterone secretion in man. Foresta, C., Mioni, R., Miotto, D., De Carlo, E., Facchin, F., Varotto, A. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  10. Optimizing the outcome of microsurgical subinguinal varicocelectomy using isosulfan blue: a prospective randomized trial. Schwentner, C., Oswald, J., Lunacek, A., Deibl, M., Bartsch, G., Radmayr, C. J. Urol. (2006) [Pubmed]
  11. Plasma testosterone in patients with varicocele and sexual inadequacy. Comhaire, F., Vermeulen, A. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  12. Factors predicting the outcome of varicocele repair for subfertility: the value of the luteinizing hormone-releasing hormone test. Bickel, A., Dickstein, G. J. Urol. (1989) [Pubmed]
  13. Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction. Mitropoulos, D., Deliconstantinos, G., Zervas, A., Villiotou, V., Dimopoulos, C., Stavrides, J. J. Urol. (1996) [Pubmed]
  14. Androgen therapy of a varicocele. Check, J.H., Rakoff, A.E. J. Urol. (1977) [Pubmed]
  15. p53 expression and apoptosis in varicocele in the rat testis. Kilinc, F., Guvel, S., Kayaselcuk, F., Aygun, C., Egilmez, T., Ozkardes, H. J. Urol. (2004) [Pubmed]
  16. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. Hendin, B.N., Kolettis, P.N., Sharma, R.K., Thomas, A.J., Agarwal, A. J. Urol. (1999) [Pubmed]
  17. Raised sodium, potassium, and urea concentrations in spermatic venous blood: an additional causative factor in the testicular dysfunction of varicocele? Adamopoulos, D.A., Kontogeorgos, L., Abrahamian-Michalakis, A., Terzis, T., Vassilopoulos, P. Fertil. Steril. (1987) [Pubmed]
  18. Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele. Chen, S.S., Chang, L.S., Chen, H.W., Wei, Y.H. Hum. Reprod. (2002) [Pubmed]
  19. The pathophysiology of varicoceles in the light of current molecular and genetic information. Marmar, J.L. Hum. Reprod. Update (2001) [Pubmed]
  20. The effect of smoking and varicocele on human sperm acrosin activity and acrosome reaction. El Mulla, K.F., Köhn, F.M., El Beheiry, A.H., Schill, W.B. Hum. Reprod. (1995) [Pubmed]
  21. Varicocele-associated decrease in antioxidant defenses. Barbieri, E.R., Hidalgo, M.E., Venegas, A., Smith, R., Lissi, E.A. J. Androl. (1999) [Pubmed]
  22. Induction of renin-angiotensin system in human testis in vivo. Okuyama, A., Nonomura, N., Koh, E., Kondoh, N., Takeyama, M., Nakamura, M., Namiki, M., Fujioka, H., Matsumoto, K., Matsuda, M. Arch. Androl. (1988) [Pubmed]
  23. Effect of experimental varicocele on the expressions of Notch 1, 2, and 3 in rat testes: an immunohistochemical study. Sahin, Z., Bayram, Z., Celik-Ozenci, C., Akkoyunlu, G., Seval, Y., Erdogru, T., Ustunel, I., Baykara, M., Demir, R. Fertil. Steril. (2005) [Pubmed]
  24. Nitric oxide synthase patterns in normal and varicocele testis in adolescents. Santoro, G., Romeo, C., Impellizzeri, P., Ientile, R., Cutroneo, G., Trimarchi, F., Pedale, S., Turiaco, N., Gentile, C. BJU international. (2001) [Pubmed]
  25. The effect of clomiphene citrate on sex hormone binding globulin in normospermic and oligozoospermic men. Adamopoulos, D.A., Vassilopoulos, P., Kapolla, N., Kontogeorgos, L. Int. J. Androl. (1981) [Pubmed]
  26. Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele. Shiraishi, K., Naito, K. Hum. Reprod. (2005) [Pubmed]
  27. Hemodynamics of the varicocele. Part II. Correlation among the results of renocaval pressure measurements, varicocele scintigraphy and phlebography. Mali, W.P., Oei, H.Y., Arndt, J.W., Kremer, J., Coolsaet, B.L., Schuur, K. J. Urol. (1986) [Pubmed]
  28. Testicular arterial perfusion in varicocele: the role of rapid sequence scintigraphy with technetium in varicocele evaluation. Comhaire, F., Simons, M., Kunnen, M., Vermeulen, L. J. Urol. (1983) [Pubmed]
  29. Physiopathologic aspects of Leydig cell function in varicocele patients. Andò, S., Giacchetto, C., Colpi, G., Beraldi, E., Panno, M.L., Lombardi, A., Sposato, G. J. Androl. (1984) [Pubmed]
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