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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.

Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.[1]

References

  1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. Jay, P., Bergé-Lefranc, J.L., Marsollier, C., Méjean, C., Taviaux, S., Berta, P. Oncogene (1997) [Pubmed]
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