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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A regulatory role for TRAF1 in antigen-induced apoptosis of T cells.

Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-kappaB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8(+) T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily.[1]


  1. A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. Speiser, D.E., Lee, S.Y., Wong, B., Arron, J., Santana, A., Kong, Y.Y., Ohashi, P.S., Choi, Y. J. Exp. Med. (1997) [Pubmed]
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