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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation.

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1-/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor- mediated synaptic transmission in the CA1 field of hippocampal slices were augmented in Thy 1/PN-1 mice and reduced in PN-1-/- mice. Compensatory changes in GABA-mediated inhibition in Thy 1/PN-1 mice suggest that altered brain PN-1 levels lead to an imbalance between excitatory and inhibitory synaptic transmission.[1]

References

  1. Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. Lüthi, A., Van der Putten, H., Botteri, F.M., Mansuy, I.M., Meins, M., Frey, U., Sansig, G., Portet, C., Schmutz, M., Schröder, M., Nitsch, C., Laurent, J.P., Monard, D. J. Neurosci. (1997) [Pubmed]
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