Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Tsutsui, S. et al.

Tsutsui, Shinomura, Higashiyama, Higashimoto, Miyazaki, Kanayama, Hiraoka, Minami, Kitamura, Murayama, Miyagawa, Taniguchi, Matsuzawa,

Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach.

The present study was designed to investigate whether heparin-binding epidermal growth factor-like growth factor and its related peptides are expressed in response to gastrin in rat stomach. Rat gastrin-17I (2.5 nmol/kg/hour) or gastrin-17I plus gastrin receptor antagonist, L-740,093 (2.0 mg/kg/hour), was injected intravenously into male Sprague-Dawley rats. RNA was extracted from oxyntic mucosa, and heparin-binding epidermal growth factor-like growth factor and related peptide gene expression was estimated using a ribonuclease protection assay. The level of transforming growth factor-alpha mRNA did not change at any time point during the experiment. In contrast, the levels of heparin-binding epidermal growth factor-like growth factor and amphiregulin mRNA were significantly increased within 3 hours following gastrin infusion and reached maximum levels 6 and 12 hours later, respectively. Continuous infusion of gastrin significantly increased oxyntic mucosal proliferation. Gastrin receptor antagonist significantly inhibited gastrin- induced heparin- binding epidermal growth factor-like growth factor and amphiregulin gene expression and gastrin-induced oxyntic mucosal proliferation. These findings indicate that heparin-binding epidermal growth factor-like growth factor and amphiregulin genes are induced by gastrin and that they play a role in the trophic action of gastrin on oxyntic mucosa.[1]

References

Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach. Tsutsui, S., Shinomura, Y., Higashiyama, S., Higashimoto, Y., Miyazaki, Y., Kanayama, S., Hiraoka, S., Minami, T., Kitamura, S., Murayama, Y., Miyagawa, J., Taniguchi, N., Matsuzawa, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]

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