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Gene Review

Areg  -  amphiregulin

Rattus norvegicus

Synonyms: AR, Amphiregulin, SDGF, Schwannoma-derived growth factor, Sdgf
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Disease relevance of Areg


High impact information on Areg


Biological context of Areg


Anatomical context of Areg


Associations of Areg with chemical compounds


Other interactions of Areg


Analytical, diagnostic and therapeutic context of Areg


  1. Identification of rat pancreatic carcinoma genes associated with lymphogenous metastasis. Tarbé, N., Lösch, S., Burtscher, H., Jarsch, M., Weidle, U.H. Anticancer Res. (2002) [Pubmed]
  2. Structure, expression and function of a schwannoma-derived growth factor. Kimura, H., Fischer, W.H., Schubert, D. Nature (1990) [Pubmed]
  3. Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells. Miyazaki, Y., Hiraoka, S., Tsutsui, S., Kitamura, S., Shinomura, Y., Matsuzawa, Y. Gastroenterology (2001) [Pubmed]
  4. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. Göoz, M., Göoz, P., Luttrell, L.M., Raymond, J.R. J. Biol. Chem. (2006) [Pubmed]
  5. Epidermal growth factor family members: endogenous mediators of the ovulatory response. Ashkenazi, H., Cao, X., Motola, S., Popliker, M., Conti, M., Tsafriri, A. Endocrinology (2005) [Pubmed]
  6. Expression of epiregulin and amphiregulin in the rat ovary. Sekiguchi, T., Mizutani, T., Yamada, K., Kajitani, T., Yazawa, T., Yoshino, M., Miyamoto, K. J. Mol. Endocrinol. (2004) [Pubmed]
  7. Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells. Miyazaki, Y., Shinomura, Y., Tsutsui, S., Yasunaga, Y., Zushi, S., Higashiyama, S., Taniguchi, N., Matsuzawa, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability. Zvibel, I., Brill, S., Halpern, Z., Papa, M. J. Cell. Biochem. (1999) [Pubmed]
  9. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Michalopoulos, G.K., Bowen, W.C., Mulè, K., Luo, J. Gene Expr. (2003) [Pubmed]
  10. Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5. Kato, M., Inazu, T., Kawai, Y., Masamura, K., Yoshida, M., Tanaka, N., Miyamoto, K., Miyamori, I. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  11. Calphostin C induces expression of amphiregulin mRNA via reactive oxygen species in IEC-6 cells. Miyazaki, Y., Shinomura, Y., Tsutsui, S., Kitamura, S., Hiraoka, S., Matsuzawa, Y. Life Sci. (1998) [Pubmed]
  12. Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy. Pattison, J.S., Folk, L.C., Madsen, R.W., Booth, F.W. J. Appl. Physiol. (2003) [Pubmed]
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