- Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Gringhuis, S.I., de Leij, L.F., Verschuren, E.W., Borger, P., Vellenga, E. Blood (1997)