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Gene Review

IL7  -  interleukin 7

Homo sapiens

Synonyms: IL-7, Interleukin-7
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Disease relevance of IL7


Psychiatry related information on IL7


High impact information on IL7


Chemical compound and disease context of IL7


Biological context of IL7


Anatomical context of IL7

  • By neutralisation of IL12 in MC cultures, indirect effects of IL7 on T cells through accessory cells were studied [20].
  • Direct effects of IL7 on isolated synovial fluid (SF) CD4+ T cells were studied by cytokine analysis [20].
  • Our data suggest that IL-7, in addition to regulating lymphocyte growth and differentiation, has potent effects on cells of the monocytic lineage [21].
  • Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes [21].
  • IL-7 was found to induce the generation of both CTL and LAK cells in bulk cultures [22].

Associations of IL7 with chemical compounds

  • An optimal concentration of IL-7 (100 ng/ml) induced monocytes to secrete 10-fold more IL-6 than an optimal concentration of IL-1 beta (10 ng/ml), and almost as much as LPS [21].
  • Interleukin-7 (IL-7) is a glycoprotein that regulates lymphocyte precursor growth and differentiation [23].
  • Tyrosine phosphorylation of several proteins (55 kd, 30 kd, and 24 kd) in HS-27a cells was rapidly increased after incubation with recombinant IL-7 [24].
  • We also show that the IL-7-induced enhancement of the AP-1-DNA binding activity is not cyclosporin A-sensitive [25].
  • Quality analysis of the hIL-7 model identified poor structural features in the carboxyl terminus that, when further studied using hydrophobic moment analysis, detected an atypical structural property in helix D, which contains Cys 130 and Cys142 [26].

Physical interactions of IL7


Regulatory relationships of IL7


Other interactions of IL7


Analytical, diagnostic and therapeutic context of IL7

  • Sézary lymphoma cells from at least three of five patients studied expressed IL7 mRNA, and skin from three of five patients studied, as well as normal skin, expressed IL7 mRNA by RT-PCR [2].
  • Collectively, these data suggest that IL-7 has potent regulatory effects on human cytolytic cell populations and, either alone or in combination with other cytokines, could be important for the in vitro expansion of cells for adoptive immunotherapy [22].
  • IL-7 production was measured by immunoassay [2].
  • PBMC were obtained from 15 patients 27 to 84 days after autologous (n = 13) or syngeneic (n = 2) bone marrow transplantation (BMT) and tested for IL-7-induced LAK activity [36].
  • Flow cytometry revealed an increase in IL-2-receptor-positive lymphocytes following incubation with IL-7 [37].


  1. Interleukin-7 is a growth factor for Sézary lymphoma cells. Dalloul, A., Laroche, L., Bagot, M., Mossalayi, M.D., Fourcade, C., Thacker, D.J., Hogge, D.E., Merle-Béral, H., Debré, P., Schmitt, C. J. Clin. Invest. (1992) [Pubmed]
  2. Costimulation of cutaneous T-cell lymphoma cells by interleukin-7 and interleukin-2: potential autocrine or paracrine effectors in the Sézary syndrome. Foss, F.M., Koc, Y., Stetler-Stevenson, M.A., Nguyen, D.T., O'Brien, M.C., Turner, R., Sausville, E.A. J. Clin. Oncol. (1994) [Pubmed]
  3. Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1. Steffens, C.M., Managlia, E.Z., Landay, A., Al-Harthi, L. Blood (2002) [Pubmed]
  4. Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells. Döbbeling, U., Dummer, R., Laine, E., Potoczna, N., Qin, J.Z., Burg, G. Blood (1998) [Pubmed]
  5. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Harada, S., Yamamura, M., Okamoto, H., Morita, Y., Kawashima, M., Aita, T., Makino, H. Arthritis Rheum. (1999) [Pubmed]
  6. Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection. Nunnari, G., Xu, Y., Acheampong, E.A., Fang, J., Daniel, R., Zhang, C., Zhang, H., Mukhtar, M., Pomerantz, R.J. J. Neurovirol. (2005) [Pubmed]
  7. Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. Sasson, S.C., Zaunders, J.J., Zanetti, G., King, E.M., Merlin, K.M., Smith, D.E., Stanley, K.K., Cooper, D.A., Kelleher, A.D. J. Infect. Dis. (2006) [Pubmed]
  8. Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes. Ducrey-Rundquist, O., Guyader, M., Trono, D. J. Virol. (2002) [Pubmed]
  9. T cell subsets and their lymphokines. De Berardinis, P. Ann. Ist. Super. Sanita (1991) [Pubmed]
  10. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Ma, A., Koka, R., Burkett, P. Annu. Rev. Immunol. (2006) [Pubmed]
  11. Control of T cell viability. Marrack, P., Kappler, J. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Goodwin, R.G., Friend, D., Ziegler, S.F., Jerzy, R., Falk, B.A., Gimpel, S., Cosman, D., Dower, S.K., March, C.J., Namen, A.E. Cell (1990) [Pubmed]
  13. Interleukin-7 and infection itself by human immunodeficiency virus 1 favor virus persistence in mature CD4(+)CD8(-)CD3(+) thymocytes through sustained induction of Bcl-2. Guillemard, E., Nugeyre, M.T., Chêne, L., Schmitt, N., Jacquemot, C., Barré-Sinoussi, F., Israël, N. Blood (2001) [Pubmed]
  14. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. Barata, J.T., Silva, A., Brandao, J.G., Nadler, L.M., Cardoso, A.A., Boussiotis, V.A. J. Exp. Med. (2004) [Pubmed]
  15. IL-12-Programmed Long-Term CD8+ T Cell Responses Require STAT4. Li, Q., Eppolito, C., Odunsi, K., Shrikant, P.A. J. Immunol. (2006) [Pubmed]
  16. Changes in eosinophil and leukocyte infiltration and expression of IL-6 and IL-7 messenger RNA in mite allergen patch test reactions in atopic dermatitis. Yamada, N., Wakugawa, M., Kuwata, S., Nakagawa, H., Tamaki, K. J. Allergy Clin. Immunol. (1996) [Pubmed]
  17. Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway. Managlia, E.Z., Landay, A., Al-Harthi, L. Virology (2006) [Pubmed]
  18. IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients. Marchetti, G., Meroni, L., Molteni, C., Taskaris, G., Gazzola, L., Galli, M., Clerici, M., Moroni, M., Franzetti, F., Gori, A. Antivir. Ther. (Lond.) (2004) [Pubmed]
  19. Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Qin, J.Z., Zhang, C.L., Kamarashev, J., Dummer, R., Burg, G., Döbbeling, U. Blood (2001) [Pubmed]
  20. Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. van Roon, J.A., Glaudemans, K.A., Bijlsma, J.W., Lafeber, F.P. Ann. Rheum. Dis. (2003) [Pubmed]
  21. Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. Alderson, M.R., Tough, T.W., Ziegler, S.F., Grabstein, K.H. J. Exp. Med. (1991) [Pubmed]
  22. Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood. Alderson, M.R., Sassenfeld, H.M., Widmer, M.B. J. Exp. Med. (1990) [Pubmed]
  23. Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes. Dadi, H.K., Roifman, C.M. J. Clin. Invest. (1993) [Pubmed]
  24. Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein. Iwata, M., Graf, L., Awaya, N., Torok-Storb, B. Blood (2002) [Pubmed]
  25. Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Gringhuis, S.I., de Leij, L.F., Verschuren, E.W., Borger, P., Vellenga, E. Blood (1997) [Pubmed]
  26. Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. Cosenza, L., Rosenbach, A., White, J.V., Murphy, J.R., Smith, T. Protein Sci. (2000) [Pubmed]
  27. IL-7 receptor is present on human microvascular endothelial cells. Duś, D., Krawczenko, A., Załecki, P., Paprocka, M., Wiedłocha, A., Goupille, C., Kieda, C. Immunol. Lett. (2003) [Pubmed]
  28. IL-7 enhances the expression of IL-3 and granulocyte-macrophage-CSF mRNA in activated human T cells by post-transcriptional mechanisms. Dokter, W.H., Sierdsema, S.J., Esselink, M.T., Halie, M.R., Vellenga, E. J. Immunol. (1993) [Pubmed]
  29. Cell surface expression of surrogate light chain (psi L) in the absence of mu on human pro-B cell lines and normal pro-B cells. Meffre, E., Fougereau, M., Argenson, J.N., Aubaniac, J.M., Schiff, C. Eur. J. Immunol. (1996) [Pubmed]
  30. Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7. Ariel, A., Hershkoviz, R., Cahalon, L., Williams, D.E., Akiyama, S.K., Yamada, K.M., Chen, C., Alon, R., Lapidot, T., Lider, O. Eur. J. Immunol. (1997) [Pubmed]
  31. Interleukin-7 (IL-7) enhances class switching to IgE and IgG4 in the presence of T cells via IL-9 and sCD23. Jeannin, P., Delneste, Y., Lecoanet-Henchoz, S., Gretener, D., Bonnefoy, J.Y. Blood (1998) [Pubmed]
  32. CD23 expression in activated human T cells is enhanced by interleukin-7. Carini, C., Fratazzi, C. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  33. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. Alves, N.L., van Leeuwen, E.M., Derks, I.A., van Lier, R.A. J. Immunol. (2008) [Pubmed]
  34. Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells. Qin, J.Z., Dummer, R., Burg, G., Döbbeling, U. Blood (1999) [Pubmed]
  35. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. Sharfe, N., Dadi, H.K., Roifman, C.M. Blood (1995) [Pubmed]
  36. Induction by interleukin-7 of lymphokine-activated killer activity in lymphocytes from autologous and syngeneic marrow transplant recipients before and after systemic interleukin-2 therapy. Pavletic, Z., Benyunes, M.C., Thompson, J.A., Lindgren, C.G., Massumoto, C., Alderson, M.R., Buckner, C.D., Fefer, A. Exp. Hematol. (1993) [Pubmed]
  37. Enhancement of interleukin-2-induced lymphokine-activated killer activity by interleukin 7 against autologous human renal cell carcinoma. Kondo, M., Nonomura, N., Miki, T., Kojima, Y., Yokoyama, M., Nakano, E., Okuyama, A. Oncology (1998) [Pubmed]
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