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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.[1]

References

  1. Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells. Kaneko, H., Neoh, L.P., Takeda, N., Akimoto, H., Hishikawa, T., Hashimoto, H., Hirose, S., Karaki, S., Takiguchi, M., Nakauchi, H., Kaneko, Y., Yamamoto, N., Sekigawa, I. J. Virol. (1997) [Pubmed]
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