- A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. Hanada, K., Hara, T., Nishijima, M., Kuge, O., Dickson, R.C., Nagiec, M.M. J. Biol. Chem. (1997)