- The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation. Basu, L., Yang, C.H., Murti, A., Garcia, J.V., Croze, E., Constantinescu, S.N., Mullersman, J.E., Pfeffer, L.M. Virology (1998)