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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.

ONO-5046 is a potent, specific and intravenously active inhibitor of neutrophil elastase. To examine the role of elastase in glomerulonephritis, we tested the effects of ONO-5046 on nephrotoxic serum (NTS) nephritis in a rat model of the disease in humans. Rats were administered ONO-5046 or phosphate-buffered saline (PBS) intraperitoneally 24 hours prior to injection of NTS, and they were then given equal doses of ONO-5046 or PBS three hours and 1, 2, 3, 4, 5 and 6 days later. Compared with the control groups, ONO-5046 significantly reduced proteinuria and hematuria, and suppressed the formation of crescentic glomeruli in a dose-dependent manner. Our results suggest that neutrophil elastase participates in NTS nephritis by degrading glomerular basement membrane proteins, and that the elastase inhibitor, ONO-5046, suppresses crescentic formation and glomerular injury caused by elastase.[1]


  1. Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats. Suzuki, S., Gejyo, F., Kuroda, T., Kazama, J.J., Imai, N., Kimura, H., Arakawa, M. Kidney Int. (1998) [Pubmed]
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