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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J.

Transcription factors regulating the process of megakaryocyte development remain largely unclarified. To clarify them further, we used a human megakaryoblastic cell line, Meg-J, which showed prominant polyploidization and augmented platelet glycoprotein (GP) Ib expression after incubation with thrombopoietin (TPO, c-mpl ligand) and K252a (an indolocarbasole derivative). Under these conditions, we analyzed the expression of the transcription factors and observed that the expression of NF-E2 p45, but not those of GATA-1, GATA-2, Tal-1/SCL, Evi-1, and MafK, was increased after TPO and K252a stimulation. Gel-shift assay confirmed the enhanced binding activity to the NF-E2 site. The abolishment of NF-E2 p45 with NF-E2 antisense oligomers inhibited TPO plus K252a-induced polyploidization. These findings suggest that NF-E2 p45 is essential for the polyploidization of megakaryocytic cells.[1]

References

  1. Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J. Kobayashi, S., Teramura, M., Ito, K., Iwabe, K., Inaba, T., Mizoguchi, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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