- The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Horikawa, Y., Ishikawa, J., Kitayama, H., Nishiura, T., Tomiyama, Y., Miyazaki, H., Matsuzawa, Y. Blood (1996)
- Effects of thrombopoietin, interleukin-3 and the kinase inhibitor K-252a on growth and polyploidization of the megakaryocytic cell line M-07e. Quentmeier, H., Zaborski, M., Drexler, H.G. Leukemia (1998)
- Pharmacologic treatment options in patients with thrombocytopenia. Demetri, G.D. Semin. Hematol. (2000)
- Thrombopoietin production in human hepatic cell cultures (HepG2) is resistant to IFN-alpha, IFN-beta, and IFN-gamma treatment. Wolber, E.M., Haase, B., Jelkmann, W. J. Interferon Cytokine Res. (2002)
- Thrombocytosis in preterm infants: a possible involvement of thrombopoietin receptor gene expression. Nakayama, H., Ihara, K., Hikino, S., Yamamoto, J., Nagatomo, T., Takemoto, M., Hara, T. J. Mol. Med. (2005)
- An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Wiestner, A., Schlemper, R.J., van der Maas, A.P., Skoda, R.C. Nat. Genet. (1998)
- Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. Fanucchi, M., Glaspy, J., Crawford, J., Garst, J., Figlin, R., Sheridan, W., Menchaca, D., Tomita, D., Ozer, H., Harker, L. N. Engl. J. Med. (1997)
- Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina. Zeevalk, G.D., Nicklas, W.J. Vision Res. (1997)
- A novel thrombopoietin signaling defect in polycythemia vera platelets. Moliterno, A.R., Siebel, K.E., Sun, A.Y., Hankins, W.D., Spivak, J.L. Stem Cells (1998)
- Thrombopoietin, interleukin-6, and P-selectin at diagnosis and during post-steroid recovery period of patients with autoimmune thrombocytopenic purpura. Haznedaroglu, I.C., Büyükaşik, Y., Koşar, A., Kirazh, S., Dündar, S.V. Ann. Hematol. (1998)
- Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia. Axelrad, A.A., Eskinazi, D., Correa, P.N., Amato, D. Blood (2000)
- Thrombopoietin in acute liver failure. Schiødt, F.V., Balko, J., Schilsky, M., Harrison, M.E., Thornton, A., Lee, W.M. Hepatology (2003)
- Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Chen, J., Herceg-Harjacek, L., Groopman, J.E., Grabarek, J. Blood (1995)
- The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Debili, N., Wendling, F., Katz, A., Guichard, J., Breton-Gorius, J., Hunt, P., Vainchenker, W. Blood (1995)
- Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Banu, N., Wang, J.F., Deng, B., Groopman, J.E., Avraham, H. Blood (1995)
- Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation. Kanaji, S., Kanaji, T., Jacquelin, B., Chang, M., Nugent, D.J., Komatsu, N., Moroi, M., Izuhara, K., Kunicki, T.J. Blood (2005)
- Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells? Della Bella, S., Nicola, S., Timofeeva, I., Villa, M.L., Santoro, A., Berardi, A.C. Blood (2004)
- Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1. Holmes, M.L., Bartle, N., Eisbacher, M., Chong, B.H. J. Biol. Chem. (2002)
- Thrombopoietin augments ex vivo expansion of human cord blood-derived hematopoietic progenitors in combination with stem cell factor and flt3 ligand. Ohmizono, Y., Sakabe, H., Kimura, T., Tanimukai, S., Matsumura, T., Miyazaki, H., Lyman, S.D., Sonoda, Y. Leukemia (1997)
- Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. Kirito, K., Watanabe, T., Sawada, K., Endo, H., Ozawa, K., Komatsu, N. J. Biol. Chem. (2002)
- Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes. Mostafa, S.S., Papoutsakis, E.T., Miller, W.M. Exp. Hematol. (2001)
- Glucose transport activation in human hematopoietic cells M07e is modulated by cytosolic calcium and calmodulin. Maraldi, T., Rugolo, M., Fiorentini, D., Landi, L., Hakim, G. Cell Calcium (2006)
- Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J. Kobayashi, S., Teramura, M., Ito, K., Iwabe, K., Inaba, T., Mizoguchi, H. Biochem. Biophys. Res. Commun. (1998)
- Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. Campus, F., Lova, P., Bertoni, A., Sinigaglia, F., Balduini, C., Torti, M. J. Biol. Chem. (2005)
- Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Majka, M., Janowska-Wieczorek, A., Ratajczak, J., Kowalska, M.A., Vilaire, G., Pan, Z.K., Honczarenko, M., Marquez, L.A., Poncz, M., Ratajczak, M.Z. Blood (2000)
- Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. Bacon, C.M., Tortolani, P.J., Shimosaka, A., Rees, R.C., Longo, D.L., O'Shea, J.J. FEBS Lett. (1995)
- Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes. Guerriero, R., Parolini, I., Testa, U., Samoggia, P., Petrucci, E., Sargiacomo, M., Chelucci, C., Gabbianelli, M., Peschle, C. J. Cell. Sci. (2006)
- Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8. Higuchi, T., Koike, K., Sawai, N., Mwamtemi, H.H., Takeuchi, K., Shiohara, M., Kikuchi, T., Yasui, K., Ito, S., Yamagami, O., Sasaki, Y., Okumura, N., Kato, T., Miyazaki, H., Ikeda, M., Yamada, M., Komiyama, A. Br. J. Haematol. (1997)
- Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines. Goncalves, F., Lacout, C., Féger, F., Cohen-Solal, K., Guichard, J., Cramer, E., Vainchenker, W., Duménil, D. Leukemia (1998)
- Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines. Drexler, H.G., Zaborski, M., Quentmeier, H. Leukemia (1997)
- Circulating levels of thrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome. Hsu, H.C., Lee, Y.M., Tsai, W.H., Jiang, M.L., Ho, C.H., Ho, C.K., Wang, S.Y. Oncology (2002)
- Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells. Kögler, G., Radke, T.F., Lefort, A., Sensken, S., Fischer, J., Sorg, R.V., Wernet, P. Exp. Hematol. (2005)
- Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders. Li, Y., Hetet, G., Kiladjian, J.J., Gardin, C., Grandchamp, B., Briere, J. Br. J. Haematol. (1996)
- Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro. Wun, T., Paglieroni, T., Hammond, W.P., Kaushansky, K., Foster, D.C. Am. J. Hematol. (1997)
- Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization. Foster, D.C., Sprecher, C.A., Grant, F.J., Kramer, J.M., Kuijper, J.L., Holly, R.D., Whitmore, T.E., Heipel, M.D., Bell, L.A., Ching, A.F. Proc. Natl. Acad. Sci. U.S.A. (1994)