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Gene Review

GATA2  -  GATA binding protein 2

Homo sapiens

Synonyms: DCML, Endothelial transcription factor GATA-2, GATA-binding protein 2, IMD21, MONOMAC, ...
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Disease relevance of GATA2


High impact information on GATA2


Chemical compound and disease context of GATA2


Biological context of GATA2


Anatomical context of GATA2

  • In this respect, we have studied the possible implication of GATA2, a transcription factor that is involved in several neuronal specification pathways, in the control of the proliferation of neural progenitors in the embryonic spinal cord [1].
  • Consistently, GATA2 also controls the proliferation capacity of mouse embryonic neuroepithelial cells in culture [1].
  • GATA2 is highly expressed in stem cells, and its expression dramatically decreases when erythroid and megakaryocytic differentiation proceeds [13].
  • GATA2 and -3 mRNA levels increased markedly during spontaneous in vitro differentiation of human cytotrophoblast cells when the cytotrophoblast cells fused to form a syncytium [14].
  • GATA2 was positive for 3/5 T-cell lines but negative for the other cell lines [15].

Associations of GATA2 with chemical compounds


Physical interactions of GATA2


Regulatory relationships of GATA2


Other interactions of GATA2


Analytical, diagnostic and therapeutic context of GATA2


  1. The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors. El Wakil, A., Francius, C., Wolff, A., Pleau-Varet, J., Nardelli, J. Development (2006) [Pubmed]
  2. Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Menghini, R., Marchetti, V., Cardellini, M., Hribal, M.L., Mauriello, A., Lauro, D., Sbraccia, P., Lauro, R., Federici, M. Circulation (2005) [Pubmed]
  3. Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10. Van Der Zwaag, B., Verzijl, H.T., Beltran-Valero De Bernabe, D., Schuster, V.L., Van Bokhoven, H., Kremer, H., Van Reen, M., Wichers, G.H., Brunner, H.G., Padberg, G.W. J. Med. Genet. (2002) [Pubmed]
  4. Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. Tsuzuki, S., Enver, T. Blood (2002) [Pubmed]
  5. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. Yamashita, K., Discher, D.J., Hu, J., Bishopric, N.H., Webster, K.A. J. Biol. Chem. (2001) [Pubmed]
  6. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W., Orkin, S.H. Nature (1994) [Pubmed]
  7. Recent progress in identifying genes regulating hematopoietic stem cell function and fate. Jordan, C.T., Van Zant, G. Curr. Opin. Cell Biol. (1998) [Pubmed]
  8. Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Briegel, K., Lim, K.C., Plank, C., Beug, H., Engel, J.D., Zenke, M. Genes Dev. (1993) [Pubmed]
  9. Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. Sebastian, S., Takayama, K., Shozu, M., Bulun, S.E. Mol. Endocrinol. (2002) [Pubmed]
  10. Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma. Kaneko, M., Yang, W., Matsumoto, Y., Watt, F., Funa, K. Exp. Cell Res. (2006) [Pubmed]
  11. Identification of cis and trans-acting transcriptional regulators in chondroinduced fibroblasts from the pre-phenotypic gene expression profile. Yates, K.E. Gene (2006) [Pubmed]
  12. Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population. Meirhaeghe, A., Tanck, M.W., Fajas, L., Janot, C., Helbecque, N., Cottel, D., Auwerx, J., Amouyel, P., Dallongeville, J. Mol. Genet. Metab. (2005) [Pubmed]
  13. Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements. Lahortiga, I., Vázquez, I., Agirre, X., Larrayoz, M.J., Vizmanos, J.L., Gozzetti, A., Calasanz, M.J., Odero, M.D. Genes Chromosomes Cancer (2004) [Pubmed]
  14. A placenta-specific enhancer of the human syncytin gene. Cheng, Y.H., Handwerger, S. Biol. Reprod. (2005) [Pubmed]
  15. Transcription factor expression in cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma. Matsuo, Y., Drexler, H.G., Harashima, A., Okochi, A., Shimizu, N., Orita, K. Hum. Cell (2004) [Pubmed]
  16. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. Dorfman, D.M., Wilson, D.B., Bruns, G.A., Orkin, S.H. J. Biol. Chem. (1992) [Pubmed]
  17. Function of GATA transcription factors in hydroxyurea-induced HEL cells. Zhang, S.B., He, Q.Y., Zhao, H., Gui, C.Y., Jiang, C., Qian, R.L. Cell Res. (2001) [Pubmed]
  18. Essential Role of GATA2 in the Negative Regulation of Thyrotropin {beta} Gene by Thyroid Hormone and Its Receptors. Matsushita, A., Sasaki, S., Kashiwabara, Y., Nagayama, K., Ohba, K., Iwaki, H., Misawa, H., Ishizuka, K., Nakamura, H. Mol. Endocrinol. (2007) [Pubmed]
  19. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., Ackerman, S.J. Blood (1993) [Pubmed]
  20. Megakaryocytic differentiation induced in 416B myeloid cells by GATA-2 and GATA-3 transgenes or 5-azacytidine is tightly coupled to GATA-1 expression. Visvader, J., Adams, J.M. Blood (1993) [Pubmed]
  21. Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. Lee, M.E., Temizer, D.H., Clifford, J.A., Quertermous, T. J. Biol. Chem. (1991) [Pubmed]
  22. Role of GATA motifs in tissue factor pathway inhibitor gene expression in malignant cells. Bajaj, M.S., Tyson, D.R., Steer, S.A., Kuppuswamy, M.N. Thromb. Res. (2001) [Pubmed]
  23. TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1. Kamesaki, H., Michaud, G.Y., Irving, S.G., Suwabe, N., Kamesaki, S., Okuma, M., Cossman, J. Blood (1996) [Pubmed]
  24. GATA-1-mediated Transcriptional Repression Yields Persistent Transcription Factor IIB-Chromatin Complexes. Martowicz, M.L., Grass, J.A., Bresnick, E.H. J. Biol. Chem. (2006) [Pubmed]
  25. GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Grass, J.A., Boyer, M.E., Pal, S., Wu, J., Weiss, M.J., Bresnick, E.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression. Tabata, M., Tarumoto, T., Ohmine, K., Furukawa, Y., Hatake, K., Ozawa, K., Hasegawa, Y., Mukai, H., Yamamoto, M., Imagawa, S. J. Cell. Physiol. (2001) [Pubmed]
  27. Endothelial cell-specific regulation of the murine endothelin-1 gene. Fadel, B.M., Boutet, S.C., Quertermous, T. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  28. GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland. Steger, D.J., Hecht, J.H., Mellon, P.L. Mol. Cell. Biol. (1994) [Pubmed]
  29. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-Aswapati, N., Radomska, H.S., Auron, P.E., Tenen, D.G., Sun, Z. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. Chun, T.H., Itoh, H., Subramanian, L., Iñiguez-Lluhí, J.A., Nakao, K. Circ. Res. (2003) [Pubmed]
  31. FLRG, member of the follistatin family, a new player in hematopoiesis. Maguer-Satta, V., Rimokh, R. Mol. Cell. Endocrinol. (2004) [Pubmed]
  32. Characterization of the 5'-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene. Reddy, S.V., Kuzhandaivelu, N., Acosta, L.G., Roodman, G.D. Bone (1995) [Pubmed]
  33. Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis. Dame, C., Sola, M.C., Fandrey, J., Rimsza, L.M., Freitag, P., Knöpfle, G., Christensen, R.D., Bungert, J. Br. J. Haematol. (2002) [Pubmed]
  34. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., Nüsslein-Volhard, C. Development (1996) [Pubmed]
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