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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Angiogenesis in P- and E-selectin-deficient mice.

OBJECTIVES: Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. METHODS: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. RESULTS: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. CONCLUSION: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.[1]

References

  1. Angiogenesis in P- and E-selectin-deficient mice. Hartwell, D.W., Butterfield, C.E., Frenette, P.S., Kenyon, B.M., Hynes, R.O., Folkman, J., Wagner, D.D. Microcirculation (New York, N.Y. : 1994) (1998) [Pubmed]
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