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Gene Review

Fgf2  -  fibroblast growth factor 2

Mus musculus

Synonyms: Basic fibroblast growth factor, FGF-2, Fgf-2, Fgfb, Fibroblast growth factor 2, ...
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Disease relevance of Fgf2


Psychiatry related information on Fgf2


High impact information on Fgf2


Chemical compound and disease context of Fgf2


Biological context of Fgf2


Anatomical context of Fgf2


Associations of Fgf2 with chemical compounds


Physical interactions of Fgf2

  • These results demonstrate that in these cells bFGF transforms cells by interacting with its receptor and that bFGF and hst/K-fgf may use the same receptor [21].
  • Despite the fact that we have observed inhibition of bFGF binding by the 18-mer phosphorothioate oligodeoxynucleotides for both the high and low affinity classes of bFGF receptor, the inhibition was sequence-selective only for the high affinity receptors [12].
  • By using purified proteins, FGF-2 is shown to directly interact through two separate domains with two RSK2 domains on both sides of the hydrophobic motif, namely the NH2-terminal kinase domain (residues 360-381) by amino acid Ser-117 and the COOH-terminal kinase domain (residues 388-400) by amino acids Leu-127 and Lys-128 [25].
  • We have also demonstrated that phosphorothioate homopolymers of cytidine and thymidine release bFGF bound to low affinity receptors in extracellular matrix (ECM) [12].
  • Finally, a good correlation was found between the time courses of ERK1 activation and 125I-EGF binding inhibition after NGF or bFGF treatment [26].
  • Mbd1 bound to the Fgf-2 promoter and regulates its expression in adult NSPCs [27].

Regulatory relationships of Fgf2


Other interactions of Fgf2


Analytical, diagnostic and therapeutic context of Fgf2


  1. Fibroblast growth factor 2 control of vascular tone. Zhou, M., Sutliff, R.L., Paul, R.J., Lorenz, J.N., Hoying, J.B., Haudenschild, C.C., Yin, M., Coffin, J.D., Kong, L., Kranias, E.G., Luo, W., Boivin, G.P., Duffy, J.J., Pawlowski, S.A., Doetschman, T. Nat. Med. (1998) [Pubmed]
  2. Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. Schultz, J.E., Witt, S.A., Nieman, M.L., Reiser, P.J., Engle, S.J., Zhou, M., Pawlowski, S.A., Lorenz, J.N., Kimball, T.R., Doetschman, T. J. Clin. Invest. (1999) [Pubmed]
  3. Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone. Okada, Y., Montero, A., Zhang, X., Sobue, T., Lorenzo, J., Doetschman, T., Coffin, J.D., Hurley, M.M. J. Biol. Chem. (2003) [Pubmed]
  4. Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb. Sullivan, C.J., Doetschman, T., Hoying, J.B. J. Appl. Physiol. (2002) [Pubmed]
  5. Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells. Ritter, E., Perry, A., Yu, J., Wang, T., Tang, L., Bieberich, E. Ann. Surg. (2008) [Pubmed]
  6. Effects of photostimulation on wound healing in diabetic mice. Yu, W., Naim, J.O., Lanzafame, R.J. Lasers in surgery and medicine. (1997) [Pubmed]
  7. Basic fibroblast growth factor ameliorates learning deficits in basal forebrain-lesioned mice. Ishihara, A., Saito, H., Nishiyama, N. Jpn. J. Pharmacol. (1992) [Pubmed]
  8. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Yayon, A., Klagsbrun, M., Esko, J.D., Leder, P., Ornitz, D.M. Cell (1991) [Pubmed]
  9. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Kandel, J., Bossy-Wetzel, E., Radvanyi, F., Klagsbrun, M., Folkman, J., Hanahan, D. Cell (1991) [Pubmed]
  10. Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2). Ridyard, M.S., Robbins, S.M. J. Biol. Chem. (2003) [Pubmed]
  11. Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. Qiao, D., Meyer, K., Mundhenke, C., Drew, S.A., Friedl, A. J. Biol. Chem. (2003) [Pubmed]
  12. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. Guvakova, M.A., Yakubov, L.A., Vlodavsky, I., Tonkinson, J.L., Stein, C.A. J. Biol. Chem. (1995) [Pubmed]
  13. Molecular regulation of UVB-induced cutaneous angiogenesis. Bielenberg, D.R., Bucana, C.D., Sanchez, R., Donawho, C.K., Kripke, M.L., Fidler, I.J. J. Invest. Dermatol. (1998) [Pubmed]
  14. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Kenyon, B.M., Browne, F., D'Amato, R.J. Exp. Eye Res. (1997) [Pubmed]
  15. FGF signalling is required for differentiation-induced cytoskeletal reorganisation and formation of actin-based processes by podocytes. Davidson, G., Dono, R., Zeller, R. J. Cell. Sci. (2001) [Pubmed]
  16. Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development. Choi, K.Y., Kim, H.J., Lee, M.H., Kwon, T.G., Nah, H.D., Furuichi, T., Komori, T., Nam, S.H., Kim, Y.J., Kim, H.J., Ryoo, H.M. Dev. Dyn. (2005) [Pubmed]
  17. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Zheng, W., Nowakowski, R.S., Vaccarino, F.M. Dev. Neurosci. (2004) [Pubmed]
  18. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J.D., Hurley, M.M. J. Clin. Invest. (2000) [Pubmed]
  19. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. Li, C.F., Hughes-Fulford, M. J. Bone Miner. Res. (2006) [Pubmed]
  20. Impaired myocardial capillarogenesis and increased adaptive capillary growth in FGF2-deficient mice. Amann, K., Faulhaber, J., Campean, V., Balajew, V., Dono, R., Mall, G., Ehmke, H. Lab. Invest. (2006) [Pubmed]
  21. Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin. Moscatelli, D., Quarto, N. J. Cell Biol. (1989) [Pubmed]
  22. Acidic and basic fibroblast growth factors are survival factors with distinctive activity in quiescent BALB/c 3T3 murine fibroblasts. Tamm, I., Kikuchi, T., Zychlinsky, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Narita, K., Staub, J., Chien, J., Meyer, K., Bauer, M., Friedl, A., Ramakrishnan, S., Shridhar, V. Cancer Res. (2006) [Pubmed]
  24. Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. Yeo, E.J., Exton, J.H. J. Biol. Chem. (1995) [Pubmed]
  25. Exogenously added fibroblast growth factor 2 (FGF-2) to NIH3T3 cells interacts with nuclear ribosomal S6 kinase 2 (RSK2) in a cell cycle-dependent manner. Soulet, F., Bailly, K., Roga, S., Lavigne, A.C., Amalric, F., Bouche, G. J. Biol. Chem. (2005) [Pubmed]
  26. Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor. Mothe, I., Ballotti, R., Tartare, S., Kowalski-Chauvel, A., Van Obberghen, E. Mol. Biol. Cell (1993) [Pubmed]
  27. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Li, X., Barkho, B.Z., Luo, Y., Smrt, R.D., Santistevan, N.J., Liu, C., Kuwabara, T., Gage, F.H., Zhao, X. J. Biol. Chem. (2008) [Pubmed]
  28. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. Ciccolini, F., Svendsen, C.N. J. Neurosci. (1998) [Pubmed]
  29. Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice. Nakamura, Y., Tensho, K., Nakaya, H., Nawata, M., Okabe, T., Wakitani, S. Bone (2005) [Pubmed]
  30. Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice. Ho, A., Blum, M. Exp. Neurol. (1997) [Pubmed]
  31. Up-regulation of fibroblast growth factor (FGF) receptor mRNA levels by basic FGF or testosterone in androgen-sensitive mouse mammary tumor cells. Saito, H., Kasayama, S., Kouhara, H., Matsumoto, K., Sato, B. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  32. Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells. Lukaszewicz, A., Savatier, P., Cortay, V., Kennedy, H., Dehay, C. J. Neurosci. (2002) [Pubmed]
  33. Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Bohnsack, B.L., Lai, L., Dolle, P., Hirschi, K.K. Genes Dev. (2004) [Pubmed]
  34. Modification of glial-neuronal cell interactions prevents photoreceptor apoptosis during light-induced retinal degeneration. Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H., Wada, K. Neuron (2000) [Pubmed]
  35. Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells. Campbell, J.S., Wenderoth, M.P., Hauschka, S.D., Krebs, E.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization. Perollet, C., Han, Z.C., Savona, C., Caen, J.P., Bikfalvi, A. Blood (1998) [Pubmed]
  37. Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. Chia, S.L., Sawaji, Y., Burleigh, A., McLean, C., Inglis, J., Saklatvala, J., Vincent, T. Arthritis Rheum. (2009) [Pubmed]
  38. Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation. Garmy-Susini, B., Delmas, E., Gourdy, P., Zhou, M., Bossard, C., Bugler, B., Bayard, F., Krust, A., Prats, A.C., Doetschman, T., Prats, H., Arnal, J.F. Circ. Res. (2004) [Pubmed]
  39. Differential growth factor production, secretion, and response by high and low metastatic variants of B16BL6 melanoma. Blanckaert, V.D., Schelling, M.E., Elstad, C.A., Meadows, G.G. Cancer Res. (1993) [Pubmed]
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