The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

proton     hydrogen(+1) cation

Synonyms: hydron, deuterium(1+), Hydrogen(1+), CHEBI:15378, FT-0627130, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of hydrogen ion


High impact information on hydrogen ion


Biological context of hydrogen ion

  • By using implant models prepared from Hydron, a hydrophilic polymer known to exhibit excellent tissue compatibility, we have found that the release rate could be precisely regulated by proper geometry, copolymer composition, concentration of ionogenic groups and cross-link density [10].
  • Hydron sponge is capable of eleciting an unusual phenomenon of woven bone formation [11].
  • The application of Hydron burn wound dressing did not adversely affect the wound healing [12].
  • We then measured contrast sensitivity with an Allergan Optical, Hydron Echelon, which is a diffractive simultaneous bifocal and a CIBA Vision, Spectrum, which is a concentric design, center-near, two-zone simultaneous vision bifocal [13].
  • In vivo release kinetics for bFGF in Hydron and Elvax were compared, and the release of bioactive bFGF from Hydron and Elvax was demonstrated in vitro [14].

Anatomical context of hydrogen ion

  • Pellets of the extract containing Hydron were implanted between the layers of the rabbit corneal stroma as an assay for angiogenic activity [15].
  • One group of IUMs was modified by using ethylene vinyl acetate to provide a high level of lateral compliance and another was modified by using a tissue-compatible Hydron coating in order to decrease the inflammatory response of the endometrium [16].
  • METHODS: Non-biodegradable Hydron pellets approximately 1.5 mm in diameter containing both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were implanted intravitreally over the optic disk of either Dutch belt rabbits or New Zealand White/Black satin cross rabbits [17].
  • New blood vessels did not form in response to HSA in Hydron or Elvax, while TGF-beta induced +4 angiogenesis accompanied by vigorous inflammation [14].
  • Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks [18].

Associations of hydrogen ion with other chemical compounds


Gene context of hydrogen ion


Analytical, diagnostic and therapeutic context of hydrogen ion

  • Uncoated laparotomy pads and pads coated with Hydron were put through an ordinary laundry procedure [27].
  • In the configuration used, the Hydron sponge did not enhance the ingrowth of bone into the Dacron for prosthesis anchorage [11].
  • Delivery of the bFGF was either by direct intramuscular injection or by the sustained release from 888polymers (Hydron or Elvax) implanted into the muscles [28].
  • The experience with clinical application of hydron pouches in tumor chemotherapy [2].
  • The tear stability and tear volume of 55 asymptomatic Hong Kong-Chinese were assessed before soft contact lens (Hydron Zero 6) were and repeated on three visits over 28 weeks of lens wear [29].


  1. Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo. Gu, W.Z., Tahir, S.K., Wang, Y.C., Zhang, H.C., Cherian, S.P., O'Connor, S., Leal, J.A., Rosenberg, S.H., Ng, S.C. Eur. J. Cancer (1999) [Pubmed]
  2. The experience with clinical application of hydron pouches in tumor chemotherapy. Koutecký, J., Tríska, J., Drobník, J., Wichterle, O. Neoplasma (1975) [Pubmed]
  3. Paresthesia of the inferior alveolar nerve caused by Hydron: a case report. Pyner, D.A. Journal of endodontics. (1980) [Pubmed]
  4. Clinical performances of two disposable soft contact lenses of different materials on Hong Kong-Chinese. Cho, P., Ng, V. Contact lens & anterior eye : the journal of the British Contact Lens Association. (2000) [Pubmed]
  5. Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Galardy, R.E., Grobelny, D., Foellmer, H.G., Fernandez, L.A. Cancer Res. (1994) [Pubmed]
  6. Real-time monitoring of the oxalate decarboxylase reaction and probing hydron exchange in the product, formate, using fourier transform infrared spectroscopy. Muthusamy, M., Burrell, M.R., Thorneley, R.N., Bornemann, S. Biochemistry (2006) [Pubmed]
  7. Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of (R)-glyceraldehyde 3-phosphate in D2O. O'Donoghue, A.C., Amyes, T.L., Richard, J.P. Biochemistry (2005) [Pubmed]
  8. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Lee, H., Cusick, R.A., Browne, F., Ho Kim, T., Ma, P.X., Utsunomiya, H., Langer, R., Vacanti, J.P. Transplantation (2002) [Pubmed]
  9. Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer. Ozerdem, U. Prostate (2006) [Pubmed]
  10. Biocompatible implants for the sustained zero-order release of narcotic antagonists. Abrahams, R.A., Ronel, S.H. J. Biomed. Mater. Res. (1975) [Pubmed]
  11. Porous hydrophilic polymer: good and bad news in the orthopedic application of cruciate ligament substitution. Rubin, R.M., Marshall, J.L. J. Biomed. Mater. Res. (1975) [Pubmed]
  12. The effect of Hydron burn wound dressing on burned rat and rabbit ear wound healing. Dressler, D.P., Barbee, W.K., Sprenger, R. The Journal of trauma. (1980) [Pubmed]
  13. Effects of target distance and pupil size on letter contrast sensitivity with simultaneous vision bifocal contact lenses. Bradley, A., Abdul Rahman, H., Soni, P.S., Zhang, X. Optometry and vision science : official publication of the American Academy of Optometry. (1993) [Pubmed]
  14. Wound healing angiogenesis: indirect stimulation by basic fibroblast growth factor. Knighton, D.R., Phillips, G.D., Fiegel, V.D. The Journal of trauma. (1990) [Pubmed]
  15. Angiogenic activity in damaged skeletal muscle. Phillips, G.D., Knighton, D.R. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  16. Two modifications of the intrauterine membrane contraceptive device. Batár, I., Thomas, M., Lampé, L., Kessel, E. Fertil. Steril. (1978) [Pubmed]
  17. Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breeds. Erb, M.H., Sioulis, C.E., Kuppermann, B.D., Osann, K., Wong, C.G. Curr. Eye Res. (2002) [Pubmed]
  18. In vivo angiogenesis by platelet-derived wound-healing formula in injured spinal cord. Hiraizumi, Y., Transfeldt, E.E., Kawahara, N., Sung, J.H., Knighton, D., Fiegel, V.D. Brain Res. Bull. (1993) [Pubmed]
  19. Effect of proteins on water and transport properties of various hydrogel contact lens materials. Mirejovsky, D., Patel, A.S., Rodriguez, D.D. Curr. Eye Res. (1991) [Pubmed]
  20. A new biomaterial for the control of infection in the burn wound. Nathan, P., Law, E.J., MacMillan, B.G., Murphy, D.F., Ronel, S.H., D'Andrea, M.J., Abrahams, R.A. Transactions - American Society for Artificial Internal Organs. (1976) [Pubmed]
  21. Red cell preservation and removal system of purine derivatives. Sasakawa, S., Honda, K., Shiba, M., Mura, T., Nakao, M., Nakagawa, S., Nakao, T., Nakashima, T., Takakura, K. Acta Biol. Med. Ger. (1981) [Pubmed]
  22. COX-2 inhibitors. A new class of antiangiogenic agents. Masferrer, J.L., Koki, A., Seibert, K. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  23. Angiogenesis in P- and E-selectin-deficient mice. Hartwell, D.W., Butterfield, C.E., Frenette, P.S., Kenyon, B.M., Hynes, R.O., Folkman, J., Wagner, D.D. Microcirculation (New York, N.Y. : 1994) (1998) [Pubmed]
  24. Suppression of corneal neovascularization by culture supernatant of human amniotic cells. Kobayashi, N., Kabuyama, Y., Sasaki, S., Kato, K., Homma, Y. Cornea (2002) [Pubmed]
  25. Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit. Wong, C.G., Rich, K.A., Liaw, L.H., Hsu, H.T., Berns, M.W. Curr. Eye Res. (2001) [Pubmed]
  26. Inhibition of corneal angiogenesis by local application of vasostatin. Wu, P.C., Yang, L.C., Kuo, H.K., Huang, C.C., Tsai, C.L., Lin, P.R., Wu, P.C., Shin, S.J., Tai, M.H. Mol. Vis. (2005) [Pubmed]
  27. The laparotomy pad, the laundry and intestinal adhesions. Miller, J.M. Am. J. Surg. (1980) [Pubmed]
  28. The exogenous administration of basic fibroblast growth factor to regenerating skeletal muscle in mice does not enhance the process of regeneration. Mitchell, C.A., McGeachie, J.K., Grounds, M.D. Growth Factors (1996) [Pubmed]
  29. Soft contact lens wear in Hong Kong-Chinese: predicting success. Chui, W.S., Cho, P., Brown, B. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (2000) [Pubmed]
WikiGenes - Universities