Ca-DTPA-induced fetal death and malformation in mice.
Increased fetal mortality and congenital malformation were induced in mice by Ca-DTPA, a chelate widely used for the removal of internally deposited plutonium in human beings. Mated C57BL/Do female mice were given five daily injections of 720-2,880 mumol/kg Ca-DTPA during early, mid, or late gestation. Damage probably occurred as a result of the depletion by Ca-DTPA of zinc and manganese, trace elements essential to growth and development. By extension, it seems likely that Ca-DTPA could damage human fetuses. A much safer chelate, Zn-DTPA, is recommended for the treatment of accidental plutonium contamination.[1]References
- Ca-DTPA-induced fetal death and malformation in mice. Fisher, D.R., Calder, S.E., Mays, C.W., Taylor, G.N. Teratology (1976) [Pubmed]
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