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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein.

The previously uncharacterized CDC24 homology domain of BCR, which is missing in the P185 BCR-ABL oncogene of Philadelphia chromosome (Ph1)-positive acute lymphocytic leukemia but is retained in P210 BCR-ABL of chronic myelogeneous leukemia, was found to bind to the xeroderma pigmentosum group B protein (XPB). The binding appeared to be required for XPB to be tyrosine- phosphorylated by BCR-ABL. The interaction not only reduced both the ATPase and the helicase activities of XPB purified in the baculovirus system but also impaired XPB-mediated cross-complementation of the repair deficiency in rodent UV-sensitive mutants of group 3. The persistent dysfunction of XPB may in part underlie genomic instability in blastic crisis.[1]

References

  1. The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein. Takeda, N., Shibuya, M., Maru, Y. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
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