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MeSH Review

Philadelphia Chromosome

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Disease relevance of Philadelphia Chromosome


High impact information on Philadelphia Chromosome


Chemical compound and disease context of Philadelphia Chromosome


Biological context of Philadelphia Chromosome


Anatomical context of Philadelphia Chromosome


Gene context of Philadelphia Chromosome


Analytical, diagnostic and therapeutic context of Philadelphia Chromosome


  1. Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. Talpaz, M., Kantarjian, H.M., McCredie, K., Trujillo, J.M., Keating, M.J., Gutterman, J.U. N. Engl. J. Med. (1986) [Pubmed]
  2. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Pendergast, A.M., Quilliam, L.A., Cripe, L.D., Bassing, C.H., Dai, Z., Li, N., Batzer, A., Rabun, K.M., Der, C.J., Schlessinger, J. Cell (1993) [Pubmed]
  3. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Thomas, D.A., Faderl, S., Cortes, J., O'Brien, S., Giles, F.J., Kornblau, S.M., Garcia-Manero, G., Keating, M.J., Andreeff, M., Jeha, S., Beran, M., Verstovsek, S., Pierce, S., Letvak, L., Salvado, A., Champlin, R., Talpaz, M., Kantarjian, H. Blood (2004) [Pubmed]
  4. Variability of the molecular defects corresponding to the presence of a Philadelphia chromosome in human hematologic malignancies. Saglio, G., Guerrasio, A., Tassinari, A., Ponzetto, C., Zaccaria, A., Testoni, P., Celso, B., Rege Cambrin, G., Serra, A., Pegoraro, L. Blood (1988) [Pubmed]
  5. Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines. Barosi, G. J. Clin. Oncol. (1999) [Pubmed]
  6. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Korsmeyer, S.J. Annu. Rev. Immunol. (1992) [Pubmed]
  7. Bone marrow transplantation for chronic granulocytic leukemia. Lehn, P., Devergie, A., Benbunan, M., Lemercier, N., Raffoux, C., Rabian, C., Vilmer, E., Azogui, O., Irti, T., Gluckman, E. J. Natl. Cancer Inst. (1986) [Pubmed]
  8. Short Y chromosome and Ph1 chromosome in acute monomyelocytic leukaemia. Padre-Mendoza, T., Forman, E.N., Farnes, P., Barker, B.E., Smith, P.S. Lancet (1978) [Pubmed]
  9. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. LaMontagne, K.R., Hannon, G., Tonks, N.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome. McLaughlin, J., Chianese, E., Witte, O.N. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., Capdeville, R., Talpaz, M. N. Engl. J. Med. (2001) [Pubmed]
  12. Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl-positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571). Scheuring, U.J., Pfeifer, H., Wassmann, B., Bruck, P., Atta, J., Petershofen, E.K., Gehrke, B., Gschaidmeier, H., Hoelzer, D., Ottmann, O.G. Blood (2003) [Pubmed]
  13. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Kamio, T., Toki, T., Kanezaki, R., Sasaki, S., Tandai, S., Terui, K., Ikebe, D., Igarashi, K., Ito, E. Blood (2003) [Pubmed]
  14. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster. Schrappe, M., Reiter, A., Zimmermann, M., Harbott, J., Ludwig, W.D., Henze, G., Gadner, H., Odenwald, E., Riehm, H. Leukemia (2000) [Pubmed]
  15. Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia: a pilot study which raises important questions. Ohyashiki, K., Ohyashiki, J.H., Tauchi, T., Fujieda, H., Hojo, H., Ohtaka, M., Saito, M., Nakazawa, S., Toyama, K. Leukemia (1991) [Pubmed]
  16. BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Skorski, T., Wlodarski, P., Daheron, L., Salomoni, P., Nieborowska-Skorska, M., Majewski, M., Wasik, M., Calabretta, B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Long-range mapping of the Philadelphia chromosome by pulsed-field gel electrophoresis. Westbrook, C.A., Rubin, C.M., Carrino, J.J., Le Beau, M.M., Bernards, A., Rowley, J.D. Blood (1988) [Pubmed]
  18. Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762). Westbrook, C.A., Hooberman, A.L., Spino, C., Dodge, R.K., Larson, R.A., Davey, F., Wurster-Hill, D.H., Sobol, R.E., Schiffer, C., Bloomfield, C.D. Blood (1992) [Pubmed]
  19. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Nowicki, M.O., Falinski, R., Koptyra, M., Slupianek, A., Stoklosa, T., Gloc, E., Nieborowska-Skorska, M., Blasiak, J., Skorski, T. Blood (2004) [Pubmed]
  20. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Muller, A.J., Young, J.C., Pendergast, A.M., Pondel, M., Landau, N.R., Littman, D.R., Witte, O.N. Mol. Cell. Biol. (1991) [Pubmed]
  21. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. de Klein, A., van Kessel, A.G., Grosveld, G., Bartram, C.R., Hagemeijer, A., Bootsma, D., Spurr, N.K., Heisterkamp, N., Groffen, J., Stephenson, J.R. Nature (1982) [Pubmed]
  22. In vitro restoration of polyclonal hematopoiesis in a chronic myelogenous leukemia after in vitro treatment with 4-hydroperoxycyclophosphamide. Degliantoni, G., Mangoni, L., Rizzoli, V. Blood (1985) [Pubmed]
  23. Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization. Bentz, M., Cabot, G., Moos, M., Speicher, M.R., Ganser, A., Lichter, P., Döhner, H. Blood (1994) [Pubmed]
  24. Recent advancements in the treatment of chronic myelogenous leukemia. O'Dwyer, M.E., Mauro, M.J., Druker, B.J. Annu. Rev. Med. (2002) [Pubmed]
  25. p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. Salgia, R., Pisick, E., Sattler, M., Li, J.L., Uemura, N., Wong, W.K., Burky, S.A., Hirai, H., Chen, L.B., Griffin, J.D. J. Biol. Chem. (1996) [Pubmed]
  26. Tyrosine phosphorylation of murine Crkl. de Jong, R., Haataja, L., Voncken, J.W., Heisterkamp, N., Groffen, J. Oncogene (1995) [Pubmed]
  27. Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells. Tari, A.M., Arlinghaus, R., Lopez-Berestein, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  28. Acute promyelocytic leukemia developing in untreated essential thrombocythemia. Sato, N., Furukawa, T., Masuko, M., Hashimoto, S., Takahashi, H., Baba, M., Inano, K., Suzuki, N., Toba, K., Fuse, I., Aizawa, Y. Am. J. Hematol. (2002) [Pubmed]
  29. Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukemia cells by both autocrine and paracrine pathways. Ikai, T., Miwa, H., Shikami, M., Hiramatsu, A., Tajima, E., Yamamoto, H., Imai, N., Hattori, A., Nishii, K., Miura, K., Satoh, A., Itoh, M., Imamura, A., Mihara, H., Katoh, Y., Nitta, M. Eur. J. Haematol. (2005) [Pubmed]
  30. Hybridization protection assay: a rapid, sensitive, and specific method for detection of Philadelphia chromosome-positive leukemias. Dhingra, K., Talpaz, M., Riggs, M.G., Eastman, P.S., Zipf, T., Ku, S., Kurzrock, R. Blood (1991) [Pubmed]
  31. Collection of peripheral-blood diploid cells from chronic myelogenous leukemia patients early in the recovery phase from myelosuppression induced by intensive-dose chemotherapy. Kantarjian, H.M., Talpaz, M., Hester, J., Feldman, E., Korbling, M., Liang, J., Rios, M.B., Smith, T.L., Calvert, L., Deisseroth, A.B. J. Clin. Oncol. (1995) [Pubmed]
  32. Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction. Radich, J.P., Kopecky, K.J., Boldt, D.H., Head, D., Slovak, M.L., Babu, R., Kirk, J., Lee, A., Kessler, P., Appelbaum, F. Leukemia (1994) [Pubmed]
  33. Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping. Markovic, V.D., Bouman, D., Bayani, J., Al-Maghrabi, J., Kamel-Reid, S., Squire, J.A. Leukemia (2000) [Pubmed]
  34. Bcr/abl recombinant DNA analysis versus karyotype in the diagnosis and therapeutic monitoring of chronic myeloid leukemia. Ayscue, L.H., Ross, D.W., Ozer, H., Rao, K., Gulley, M.L., Dent, G.A. Am. J. Clin. Pathol. (1990) [Pubmed]
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