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Gene Review

Ly6e  -  lymphocyte antigen 6 complex, locus E

Mus musculus

 
 
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Disease relevance of Ly6e

  • The gene that encodes trypomastigote surface Ag-1 (TSA-1), a major surface Ag of the bloodstream trypomastigote stage of Trypanosoma cruzi, was expressed in a baculovirus expression system [1].
  • The ability to induce significant murine anti-T. cruzi protective immunity by immunization with plasmid DNA expressing TSA-1 provides the basis for the application of this technology in the design of optimal DNA multicomponent anti-T. cruzi vaccines which may ultimately be used for the prevention or treatment of Chagas' disease [2].
  • Increased expression of TSA-1, a member of the Ly-6 family, has previously been reported in response to proteinuria [3].
 

High impact information on Ly6e

 

Biological context of Ly6e

 

Anatomical context of Ly6e

 

Associations of Ly6e with chemical compounds

  • Hybridoma supernatants elicited against a phosphonate derivative, the TSA1, were screened by a three-step screening process: step 1, ELISA for TSA1-BSA; step 2, ELISA for the short TSA4; and step 3, competitive-inhibition by the short TSA2 [12].
 

Other interactions of Ly6e

 

Analytical, diagnostic and therapeutic context of Ly6e

  • MTS 35, a mAb specific for TSA-1, alters T cell differentiation when added to fetal thymic organ cultures, suggesting TSA-1 may be important for T cell development in the thymus [6].
  • In contrast, vaccination with the amino proximal region of TSA-1 elicits a protective immune response [1].
  • As seen by Western blotting, both mice and rabbits immunized with recombinant TSA-1 protein, as well as T. cruzi-infected mice, developed strong immune responses to the carboxyl-proximal region of TSA-1, but show no reaction to the amino-proximal portion of TSA-1 [1].
  • Previous work showed that immunotherapy with a DNA vaccine encoding Trypanosoma cruzi antigen TSA-1 reduced cardiac tissue damage and improved survival in mice when administered during the acute or chronic phases of T. cruzi infection [15].

References

  1. Identification of immunodominant epitopes in Trypanosoma cruzi trypomastigote surface antigen-1 protein that mask protective epitopes. Wrightsman, R.A., Dawson, B.D., Fouts, D.L., Manning, J.E. J. Immunol. (1994) [Pubmed]
  2. Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Wizel, B., Garg, N., Tarleton, R.L. Infect. Immun. (1998) [Pubmed]
  3. Identification of differentially expressed genes in mouse kidney after irradiation using microarray analysis. Kruse, J.J., te Poele, J.A., Velds, A., Kerkhoven, R.M., Boersma, L.J., Russell, N.S., Stewart, F.A. Radiat. Res. (2004) [Pubmed]
  4. Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2. Noda, S., Kosugi, A., Saitoh, S., Narumiya, S., Hamaoka, T. J. Exp. Med. (1996) [Pubmed]
  5. Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins. Classon, B.J., Coverdale, L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. MacNeil, I., Kennedy, J., Godfrey, D.I., Jenkins, N.A., Masciantonio, M., Mineo, C., Gilbert, D.J., Copeland, N.G., Boyd, R.L., Zlotnik, A. J. Immunol. (1993) [Pubmed]
  7. Functional characterization of hepatoma-specific stem cell antigen-2. He, J., Chang, L.J. Mol. Carcinog. (2004) [Pubmed]
  8. Stem cell antigen 2 expression in adult and developing mice. Antica, M., Wu, L., Scollay, R. Immunol. Lett. (1997) [Pubmed]
  9. Genomic organization and expression of mouse thymic shared antigen-1 (TSA-1): evidence for a processed pseudogene. Classon, B.J., Coverdale, L. Immunogenetics (1996) [Pubmed]
  10. Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2). Saitoh, S., Kosugi, A., Noda, S., Yamamoto, N., Ogata, M., Minami, Y., Miyake, K., Hamaoka, T. J. Immunol. (1995) [Pubmed]
  11. SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. Tulin, E.E., Onoda, N., Nakata, Y., Maeda, M., Hasegawa, M., Nomura, H., Kitamura, T. J. Immunol. (2003) [Pubmed]
  12. Efficient screening for catalytic antibodies using a short transition-state analog and detailed characterization of selected antibodies. Takahashi, N., Kakinuma, H., Hamada, K., Shimazaki, K., Takahashi, K., Niihata, S., Aoki, Y., Matsushita, H., Nishi, Y. Eur. J. Biochem. (1999) [Pubmed]
  13. T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis. Mirosavljevic, D., Quinn, J.M., Elliott, J., Horwood, N.J., Martin, T.J., Gillespie, M.T. J. Bone Miner. Res. (2003) [Pubmed]
  14. Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Garg, N., Tarleton, R.L. Infect. Immun. (2002) [Pubmed]
  15. Control of Trypanosoma cruzi infection and changes in T-cell populations induced by a therapeutic DNA vaccine in mice. Zapata-Estrella, H., Hummel-Newell, C., Sanchez-Burgos, G., Escobedo-Ortegon, J., Ramirez-Sierra, M.J., Arjona-Torres, A., Dumonteil, E. Immunol. Lett. (2006) [Pubmed]
 
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