Gene Review:
GRM1 - glutamate receptor, metabotropic 1
Homo sapiens
Synonyms:
GPRC1A, MGLU1, MGLUR1, Metabotropic glutamate receptor 1, PPP1R85, ...
Ossowska,
Konieczny,
Wardas,
Pietraszek,
Kuter,
Wolfarth,
Pilc,
Anneser,
Chahli,
Ince,
Borasio,
Shaw,
Aronica,
Gorter,
Ijlst-Keizers,
Rozemuller,
Yankaya,
Leenstra,
Troost,
Kew,
Kemp,
Schoepp,
Johnson,
Wright,
Salhoff,
Mayne,
Wu,
Cockerman,
Burnett,
Belegaje,
Bleakman,
Monn,
Dravolina,
Danysz,
Bespalov,
- Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Pollock, P.M., Cohen-Solal, K., Sood, R., Namkoong, J., Martino, J.J., Koganti, A., Zhu, H., Robbins, C., Makalowska, I., Shin, S.S., Marin, Y., Roberts, K.G., Yudt, L.M., Chen, A., Cheng, J., Incao, A., Pinkett, H.W., Graham, C.L., Dunn, K., Crespo-Carbone, S.M., Mackason, K.R., Ryan, K.B., Sinsimer, D., Goydos, J., Reuhl, K.R., Eckhaus, M., Meltzer, P.S., Pavan, W.J., Trent, J.M., Chen, S. Nat. Genet. (2003)
- Glutamate metabotropic receptors as targets for drug therapy in epilepsy. Moldrich, R.X., Chapman, A.G., De Sarro, G., Meldrum, B.S. Eur. J. Pharmacol. (2003)
- An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats. Ossowska, K., Konieczny, J., Wardas, J., Pietraszek, M., Kuter, K., Wolfarth, S., Pilc, A. Amino Acids (2007)
- Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors. Frauli, M., Neuville, P., Vol, C., Pin, J.P., Prézeau, L. Neuropharmacology (2006)
- Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes. Albasanz, J.L., Dalfó, E., Ferrer, I., Martín, M. Neurobiol. Dis. (2005)
- Ionotropic and metabotropic glutamate receptor structure and pharmacology. Kew, J.N., Kemp, J.A. Psychopharmacology (Berl.) (2005)
- Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. Hou, L., Antion, M.D., Hu, D., Spencer, C.M., Paylor, R., Klann, E. Neuron (2006)
- Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. Dravolina, O.A., Danysz, W., Bespalov, A.Y. Psychopharmacology (Berl.) (2006)
- Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Linden, A.M., Shannon, H., Baez, M., Yu, J.L., Koester, A., Schoepp, D.D. Psychopharmacology (Berl.) (2005)
- Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Bashir, Z.I., Bortolotto, Z.A., Davies, C.H., Berretta, N., Irving, A.J., Seal, A.J., Henley, J.M., Jane, D.E., Watkins, J.C., Collingridge, G.L. Nature (1993)
- Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Aronica, E., Gorter, J.A., Ijlst-Keizers, H., Rozemuller, A.J., Yankaya, B., Leenstra, S., Troost, D. Eur. J. Neurosci. (2003)
- NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. Olszewski, R.T., Bukhari, N., Zhou, J., Kozikowski, A.P., Wroblewski, J.T., Shamimi-Noori, S., Wroblewska, B., Bzdega, T., Vicini, S., Barton, F.B., Neale, J.H. J. Neurochem. (2004)
- Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model. Avedissian, M., Longo, B.M., Jaqueta, C.B., Schnabel, B., Paiva, P.B., Mello, L.E., Briones, M.R. Hippocampus (2007)
- A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover. Pickering, D.S., Thomsen, C., Suzdak, P.D., Fletcher, E.J., Robitaille, R., Salter, M.W., MacDonald, J.F., Huang, X.P., Hampson, D.R. J. Neurochem. (1993)
- LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats. Helton, D.R., Tizzano, J.P., Monn, J.A., Schoepp, D.D., Kallman, M.J. Neuropharmacology (1997)
- Assignment of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization. Ganesh, S., Amano, K., Yamakawa, K. Cytogenet. Cell Genet. (2000)
- Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. Bruno, V., Battaglia, G., Copani, A., D'Onofrio, M., Di Iorio, P., De Blasi, A., Melchiorri, D., Flor, P.J., Nicoletti, F. J. Cereb. Blood Flow Metab. (2001)
- Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes. Frati, C., Marchese, C., Fisichella, G., Copani, A., Nasca, M.R., Storto, M., Nicoletti, F. J. Cell. Physiol. (2000)
- Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells. Luyt, K., Varadi, A., Molnar, E. J. Neurochem. (2003)
- The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors. Schoepp, D.D., Salhoff, C.R., Wright, R.A., Johnson, B.G., Burnett, J.P., Mayne, N.G., Belagaje, R., Wu, S., Monn, J.A. Neuropharmacology (1996)
- Neutrophil-derived glutamate regulates vascular endothelial barrier function. Collard, C.D., Park, K.A., Montalto, M.C., Alapati, S., Buras, J.A., Stahl, G.L., Colgan, S.P. J. Biol. Chem. (2002)
- Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. Anneser, J.M., Chahli, C., Ince, P.G., Borasio, G.D., Shaw, P.J. J. Neuropathol. Exp. Neurol. (2004)
- Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene. Cha, J.H., Kosinski, C.M., Kerner, J.A., Alsdorf, S.A., Mangiarini, L., Davies, S.W., Penney, J.B., Bates, G.P., Young, A.B. Proc. Natl. Acad. Sci. U.S.A. (1998)
- BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Carroll, F.Y., Stolle, A., Beart, P.M., Voerste, A., Brabet, I., Mauler, F., Joly, C., Antonicek, H., Bockaert, J., Müller, T., Pin, J.P., Prézeau, L. Mol. Pharmacol. (2001)
- LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Mayne, N.G., Wu, S., Cockerman, S.L., Burnett, J.P., Belegaje, R., Bleakman, D., Monn, J.A. Neuropharmacology (1997)
- Glutamate receptors: brain function and signal transduction. Nakanishi, S., Nakajima, Y., Masu, M., Ueda, Y., Nakahara, K., Watanabe, D., Yamaguchi, S., Kawabata, S., Okada, M. Brain Res. Brain Res. Rev. (1998)
- The metabotropic glutamate receptor mGluR4, but not mGluR1 alpha, is palmitoylated when expressed in BHK cells. Alaluf, S., Mulvihill, E.R., McIlhinney, R.A. J. Neurochem. (1995)
- Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Lee, R.K., Wurtman, R.J., Cox, A.J., Nitsch, R.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Contrasting roles of protein kinase C in induction versus suppression of group I mGluR-mediated epileptogenesis in vitro. Cuellar, J.C., Griffith, E.L., Merlin, L.R. J. Neurophysiol. (2005)
- LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Kingston, A.E., Ornstein, P.L., Wright, R.A., Johnson, B.G., Mayne, N.G., Burnett, J.P., Belagaje, R., Wu, S., Schoepp, D.D. Neuropharmacology (1998)
- Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Wright, R.A., Arnold, M.B., Wheeler, W.J., Ornstein, P.L., Schoepp, D.D. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- Expression and sequences of genes encoding glutamate receptors and transporters in primate retina determined using 3'-end amplification polymerase chain reaction. Hanna, M.C., Calkins, D.J. Mol. Vis. (2006)
- Metabotropic glutamate and GABA(B) receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells. Brice, N.L., Varadi, A., Ashcroft, S.J., Molnar, E. Diabetologia (2002)
- Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. Gillard, S.E., Tzaferis, J., Tsui, H.C., Kingston, A.E. J. Comp. Neurol. (2003)
- Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Page, A.J., Young, R.L., Martin, C.M., Umaerus, M., O'Donnell, T.A., Cooper, N.J., Coldwell, J.R., Hulander, M., Mattsson, J.P., Lehmann, A., Blackshaw, L.A. Gastroenterology (2005)
- Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mundell, S.J., Matharu, A.L., Pula, G., Holman, D., Roberts, P.J., Kelly, E. Mol. Pharmacol. (2002)