Gene Review:
SMAD6 - SMAD family member 6
Homo sapiens
Synonyms:
AOVD2, HsT17432, MAD homolog 6, MADH6, MADH7, ...
- Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring. Yu, H., Bock, O., Bayat, A., Ferguson, M.W., Mrowietz, U. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. (2006)
- SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Springer, J., Scholz, F.R., Peiser, C., Groneberg, D.A., Fischer, A. Biol. Chem. (2004)
- Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma. Osawa, H., Nakajima, M., Kato, H., Fukuchi, M., Kuwano, H. Anticancer Res. (2004)
- Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Liu, X., Lee, J., Cooley, M., Bhogte, E., Hartley, S., Glick, A. Cancer Res. (2003)
- Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., Iwamoto, I. J. Clin. Invest. (1999)
- Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Hata, A., Lagna, G., Massagué, J., Hemmati-Brivanlou, A. Genes Dev. (1998)
- The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Pimanda, J.E., Donaldson, I.J., de Bruijn, M.F., Kinston, S., Knezevic, K., Huckle, L., Piltz, S., Landry, J.R., Green, A.R., Tannahill, D., Göttgens, B. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Topper, J.N., Cai, J., Qiu, Y., Anderson, K.R., Xu, Y.Y., Deeds, J.D., Feeley, R., Gimeno, C.J., Woolf, E.A., Tayber, O., Mays, G.G., Sampson, B.A., Schoen, F.J., Gimbrone, M.A., Falb, D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Kaiser, M., Haag, J., Söder, S., Bau, B., Aigner, T. Arthritis Rheum. (2004)
- Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. Ishisaki, A., Yamato, K., Hashimoto, S., Nakao, A., Tamaki, K., Nonaka, K., ten Dijke, P., Sugino, H., Nishihara, T. J. Biol. Chem. (1999)
- A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling. Bai, S., Cao, X. J. Biol. Chem. (2002)
- The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications. Ichijo, T., Voutetakis, A., Cotrim, A.P., Bhattachryya, N., Fujii, M., Chrousos, G.P., Kino, T. J. Biol. Chem. (2005)
- Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells. Sugama, R., Koike, T., Imai, Y., Nomura-Furuwatari, C., Takaoka, K. Bone (2006)
- Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. Glesne, D., Huberman, E. Oncogene (2006)
- Smads oppose Hox transcriptional activities. Li, X., Nie, S., Chang, C., Qiu, T., Cao, X. Exp. Cell Res. (2006)
- Smad6 as a transcriptional corepressor. Bai, S., Shi, X., Yang, X., Cao, X. J. Biol. Chem. (2000)
- Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1). Pardali, K., Kowanetz, M., Heldin, C.H., Moustakas, A. J. Cell. Physiol. (2005)
- Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells. Tsunobuchi, H., Ishisaki, A., Imamura, T. Biochem. Biophys. Res. Commun. (2004)
- Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Nguyen, L.N., Furuya, M.H., Wolfraim, L.A., Nguyen, A.P., Holdren, M.S., Campbell, J.S., Knight, B., Yeoh, G.C., Fausto, N., Parks, W.T. Hepatology (2007)
- STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Datta, P.K., Moses, H.L. Mol. Cell. Biol. (2000)
- Frequency of Smad gene mutations in human cancers. Riggins, G.J., Kinzler, K.W., Vogelstein, B., Thiagalingam, S. Cancer Res. (1997)
- Adrenomedullin impairs the profibrotic effects of transforming growth factor-beta1 through recruiting Smad6 protein in human renal tubular cells. Huang, H., Ma, C., Yang, M., Tang, C., Wang, H. Cell. Physiol. Biochem. (2005)