Gene Review:
PLA2G6 - phospholipase A2, group VI (cytosolic,...
Homo sapiens
Synonyms:
85/88 kDa calcium-independent phospholipase A2, CaI-PLA2, GVI, GVI PLA2, Group VI phospholipase A2, ...
- Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. Jenkins, C.M., Mancuso, D.J., Yan, W., Sims, H.F., Gibson, B., Gross, R.W. J. Biol. Chem. (2004)
- Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1. Ma, Z., Wang, X., Nowatzke, W., Ramanadham, S., Turk, J. J. Biol. Chem. (1999)
- PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Morgan, N.V., Westaway, S.K., Morton, J.E., Gregory, A., Gissen, P., Sonek, S., Cangul, H., Coryell, J., Canham, N., Nardocci, N., Zorzi, G., Pasha, S., Rodriguez, D., Desguerre, I., Mubaidin, A., Bertini, E., Trembath, R.C., Simonati, A., Schanen, C., Johnson, C.A., Levinson, B., Woods, C.G., Wilmot, B., Kramer, P., Gitschier, J., Maher, E.R., Hayflick, S.J. Nat. Genet. (2006)
- PLA2G6 Mutation Underlies Infantile Neuroaxonal Dystrophy. Khateeb, S., Flusser, H., Ofir, R., Shelef, I., Narkis, G., Vardi, G., Shorer, Z., Levy, R., Galil, A., Elbedour, K., Birk, O.S. Am. J. Hum. Genet. (2006)
- Identification and distribution of endoplasmic reticulum iPLA2. Kinsey, G.R., Cummings, B.S., Beckett, C.S., Saavedra, G., Zhang, W., McHowat, J., Schnellmann, R.G. Biochem. Biophys. Res. Commun. (2005)
- I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, K.B. J. Exp. Med. (2002)
- The Galpha protein controls a pH-dependent signal path to the induction of phytoalexin biosynthesis in Eschscholzia californica. Viehweger, K., Schwartze, W., Schumann, B., Lein, W., Roos, W. Plant Cell (2006)
- Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine. Seleznev, K., Zhao, C., Zhang, X.H., Song, K., Ma, Z.A. J. Biol. Chem. (2006)
- Nitrite/nitrate (NOX) and type II phospholipase A2, leukotriene B4, and platelet-activating factor levels in patients with septic shock. Nakae, H., Endo, S., Inada, K., Yaegashi, Y., Takakuwa, T., Yamada, Y., Arakawa, N., Suzuki, T., Taniguchi, S., Shimamura, T., Ogawa, M., Teraoka, H. Res. Commun. Mol. Pathol. Pharmacol. (1996)
- A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia. Yu, Y., Tao, R., Shi, J., Zhang, X., Kou, C., Guo, Y., Zhang, X., Lin, X., Liu, S., Ju, G., Xu, Q., Shang, H., Shen, Y., Wei, J. Prostaglandins Leukot. Essent. Fatty Acids (2005)
- Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra. Duan, L., Gan, H., Arm, J., Remold, H.G. J. Immunol. (2001)
- Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation. Atsumi, G., Tajima, M., Hadano, A., Nakatani, Y., Murakami, M., Kudo, I. J. Biol. Chem. (1998)
- Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. Larsson, P.K., Claesson, H.E., Kennedy, B.P. J. Biol. Chem. (1998)
- Role of group VIA calcium-independent phospholipase A2 in arachidonic acid release, phospholipid fatty acid incorporation, and apoptosis in U937 cells responding to hydrogen peroxide. Pérez, R., Melero, R., Balboa, M.A., Balsinde, J. J. Biol. Chem. (2004)
- The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. Larsson Forsell, P.K., Kennedy, B.P., Claesson, H.E. Eur. J. Biochem. (1999)
- Ca(2+)-independent phospholipase A2 is required for alpha2-adrenergic-induced preadipocyte spreading. Pagès, C., Rey, A., Lafontan, M., Valet, P., Saulnier-Blache, J.S. Biochem. Biophys. Res. Commun. (1999)
- Catalytic features, regulation and function of myocardial phospholipase A2. McHowat, J., Creer, M.H. Current medicinal chemistry. Cardiovascular and hematological agents. (2004)
- The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2. Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M.V., Tischfield, J.A., Kudo, I. J. Biol. Chem. (1998)
- Quantitative structure-activity relationship (QSAR) analysis of a series of indole analogues as inhibitor for human group V secretory phospholipase A2. OmPraba, G., Velmurugan, D. Indian J. Biochem. Biophys. (2006)
- A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs. Tang, J., Kriz, R.W., Wolfman, N., Shaffer, M., Seehra, J., Jones, S.S. J. Biol. Chem. (1997)
- Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. Meyer, M.C., Creer, M.H., McHowat, J. Am. J. Physiol., Cell Physiol. (2005)
- Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells. Tay, H.K., Melendez, A.J. J. Biol. Chem. (2004)
- Stimulation of protease activated receptors on RT4 cells mediates arachidonic acid release via Ca2+ independent phospholipase A2. McHowat, J., Creer, M.H., Rickard, A. J. Urol. (2001)
- Relationship between plasma levels of type II phospholipase A2, PAF acetylhydrolase, endothelin-1, and thrombomodulin in patients with infected burns. Takakuwa, T., Endo, S., Nakae, H., Yamada, Y., Inada, K., Yoshida, M., Ogawa, M., Uchida, K. Res. Commun. Mol. Pathol. Pharmacol. (1994)
- Increased calcium-independent phospholipase A2 activity in first but not in multiepisode chronic schizophrenia. Smesny, S., Kinder, D., Willhardt, I., Rosburg, T., Lasch, J., Berger, G., Sauer, H. Biol. Psychiatry (2005)
- Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. Tithof, P.K., Elgayyar, M., Cho, Y., Guan, W., Fisher, A.B., Peters-Golden, M. FASEB J. (2002)