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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 106 documents. Results 1 - 10.

Homo sapiens
Gene: ... AMP response element binding protein( CREB) transcription factor was also apparent in all stimulated MC1R...Disease relevance of MC1R In contrast, variants of the melanocortin- 1 receptor gene, MC1R, confer much lower melanoma risk but are common in European populations. This link between p16 and MC1R may... / Synonyms: MC1-R
Mus musculus
Gene: ... Disease relevance of Mc1r We found that the human melanocortin 1 receptor( MC1R) and its mouse ortholog( Mc1r) undergo homologous desensitization in melanoma cells. Moreover, spontaneous dominant... of other MCR subtypes. Crucial role of the melanocortin receptor MC1R in experimental colitis. In young... / Synonyms: MC1-R
Canis lupus familiaris
Gene: ... High impact information on MC1R The amino acid sequence for the melanocortin receptor 1 gene( MC1R) was examined in 17 dogs with melanistic masks from seven breeds, 19 dogs without melanistic masks, and 7 dogs in which their coat color made the mask difficult to distinguish. An SNP is used to map MC1R to dog... / Synonyms: MC1-R
Bos taurus
Gene: ... Disease relevance of MC1R Evidence for increased alpha MSH receptor binding in the F1 variant of B16 melanoma cells grown in dialyzed fetal calf serum. High impact information on MC1R Molecular... five bovine microsatellite markers we have mapped the sheep MC1- R gene to chromosome 14, corresponding... / Synonyms: MC1-R
Sus scrofa
Gene: ... High impact information on MC1R This methodology was then used to test the effects of the fourth melanocortin receptor( MC4R) on production traits in the pig. A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pigs. A previous comparison of partial MC1R... / Synonyms: MC1-R
Felis catus
Gene: ... Disease relevance of MC1R To investigate the genetic basis, adaptive significance, and evolutionary history of melanistic variants in the Felidae, we mapped, cloned, and sequenced the cat homologs of two putative candidate genes for melanism( ASIP[ agouti] and MC1R) and identified three independent deletions...
Pan troglodytes
Gene: ... High impact information on MC1R Human DNA sequence variation in a 6. 6- kb region containing the melanocortin 1 receptor promoter. The melanocortin 1 receptor( MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are known in many mammals....
Gallus gallus
Gene: ... Disease relevance of MC1R The conserved molecular basis for the evolution of melanism in birds and several other vertebrates is probably related to low pleiotropic effects at the MC1R. High impact information on MC1R A candidate gene for this color difference is the melanocortin- 1 receptor( MC1R ), a key...
MeSH term: ... predisposition to skin cancer. Altered cell surface expression of human MC1R variant receptor alleles associated...Disease relevance of Skin Neoplasms Although all patients experienced mucocutaneous toxic effects, and triglyceride, liver- function, or skeletal abnormalities developed in some, high- dose oral isotretinoin...
MeSH term: ... context of Nevus The relationships between MC1R gene variants and red hair, skin reflectance, degree... as all nevus cells but showed differences in function of both alpha3 and alpha6 integrin subunits... expressed by all strains of congenital nevus cells and dermal fibroblasts. In addition to craniosynostosis...

 

 
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