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Gene Review

MC1R  -  melanocortin 1 receptor (alpha melanocyte...

Bos taurus

Synonyms: MC1-R, MSHR
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Disease relevance of MC1R


High impact information on MC1R


Biological context of MC1R


Analytical, diagnostic and therapeutic context of MC1R

  • A DNA extraction from cheese, a preamplification of the gene and a competitive oligonuleotide priming PCR on MC1R mutations were performed [9].
  • A new allele, named E1, was found in either homozygous (E1/E1) or heterozygous (E1/E) individuals in Aubrac and Gasconne breeds. This allele displayed a 4 amino acid duplication (12 nucleotides) located within the third cytoplasmic loop of the receptor, a region known to interact with G proteins. A first genotyping assay of the main French cattle breeds is described based on these four extension alleles [10] .


  1. Evidence for increased alpha MSH receptor binding in the F1 variant of B16 melanoma cells grown in dialyzed fetal calf serum. McQuillan, A., Hutchinson, M., Panasci, L.C. J. Cell. Physiol. (1989) [Pubmed]
  2. Molecular cloning of a bovine MSH receptor which is highly expressed in the testis. Vanetti, M., Schönrock, C., Meyerhof, W., Höllt, V. FEBS Lett. (1994) [Pubmed]
  3. Mapping and characterization of the dominant black colour locus in sheep. Våge, D.I., Fleet, M.R., Ponz, R., Olsen, R.T., Monteagudo, L.V., Tejedor, M.T., Arruga, M.V., Gagliardi, R., Postiglioni, A., Nattrass, G.S., Klungland, H. Pigment Cell Res. (2003) [Pubmed]
  4. Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex. Liakos, P., Chambaz, E.M., Feige, J.J., Defaye, G. Mol. Cell. Endocrinol. (2000) [Pubmed]
  5. Rapid communication: melanocyte stimulating hormone receptor (MC1R) maps to bovine chromosome 18. Werth, L.A., Hawkins, G.A., Eggen, A., Petit, E., Elduque, C., Kreigesmann, B., Bishop, M.D. J. Anim. Sci. (1996) [Pubmed]
  6. TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow? Berryere, T.G., Schmutz, S.M., Schimpf, R.J., Cowan, C.M., Potter, J. Anim. Genet. (2003) [Pubmed]
  7. The melanocyte-stimulating hormone receptor (MC1-R) gene as a tool in evolutionary studies of artiodactyles. Klungland, H., Røed, K.H., Nesbø, C.L., Jakobsen, K.S., Våge, D.I. Hereditas (1999) [Pubmed]
  8. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. Klungland, H., Våge, D.I., Gomez-Raya, L., Adalsteinsson, S., Lien, S. Mamm. Genome (1995) [Pubmed]
  9. Holstein's milk detection in cheeses inferred from melanocortin receptor 1 (MC1R) gene polymorphism. Maudet, C., Taberlet, P. J. Dairy Sci. (2002) [Pubmed]
  10. A first genotyping assay of French cattle breeds based on a new allele of the extension gene encoding the melanocortin-1 receptor (Mc1r). Rouzaud, F., Martin, J., Gallet, P.F., Delourme, D., Goulemot-Leger, V., Amigues, Y., Ménissier, F., Levéziel, H., Julien, R., Oulmouden, A. Genet. Sel. Evol. (2000) [Pubmed]
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