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Gene Review

MC1R  -  melanocortin 1 receptor (alpha melanocyte...

Sus scrofa

Synonyms: MC1-R, MSH-R
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High impact information on MC1R


Biological context of MC1R


Associations of MC1R with chemical compounds

  • Chinese White Rongchang Pig Does Not Have the Dominant White Allele of KIT but Has the Dominant Black Allele of MC1R [4].
  • The effect of 0.1 microM ACTH on luminal EHEC adherence was prevented in tissues pretreated contraluminally with the type 2 melanocortin receptor antagonist ACTH7-38, the neuronal conduction blocker saxitoxin, or the muscarinic cholinergic antagonist atropine [8].

Analytical, diagnostic and therapeutic context of MC1R

  • Sequence analysis of MC1R from seven porcine breeds revealed a total of four allelic variants corresponding to five different E alleles [3].


  1. Candidate gene analysis for quantitative traits using the transmission disequilibrium test: the example of the melanocortin 4-receptor in pigs. Hernández-Sánchez, J., Visscher, P., Plastow, G., Haley, C. Genetics (2003) [Pubmed]
  2. A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pigs. Kijas, J.M., Moller, M., Plastow, G., Andersson, L. Genetics (2001) [Pubmed]
  3. Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Kijas, J.M., Wales, R., Törnsten, A., Chardon, P., Moller, M., Andersson, L. Genetics (1998) [Pubmed]
  4. Chinese White Rongchang Pig Does Not Have the Dominant White Allele of KIT but Has the Dominant Black Allele of MC1R. Lai, F., Ren, J., Ai, H., Ding, N., Ma, J., Zeng, D., Chen, C., Guo, Y., Huang, L. J. Hered. (2007) [Pubmed]
  5. Genetic analysis of the KIT and MC1R genes in Chinese indigenous pigs with belt-like coat color phenotypes. Xu, G.L., Ren, J., Ding, N.S., Ai, H.S., Guo, Y.M., Chen, C.Y., Huang, L.S. Anim. Genet. (2006) [Pubmed]
  6. Single nucleotide polymorphism analysis on melanocortin receptor 1 (MC1R) of Chinese native pig. Shi, K., Wang, A., Li, N., Deng, X. Sci. China, C, Life Sci. (2004) [Pubmed]
  7. The extension coat color locus and the loci for blood group O and tyrosine aminotransferase are on pig chromosome 6. Mariani, P., Moller, M.J., Høyheim, B., Marklund, L., Davies, W., Ellegren, H., Andersson, L. J. Hered. (1996) [Pubmed]
  8. Adrenocorticotrophic hormone modulates Escherichia coli O157:H7 adherence to porcine colonic mucosa. Schreiber, K.L., Brown, D.R. Stress (Amsterdam, Netherlands) (2005) [Pubmed]
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