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Chemical Compound Review:

Indoxyl sulfate 3-sulfooxy-1H-indole

Synonyms: SureCN15755, CHEMBL1233636, CHEBI:43355, HMDB00682, AC1L1UTK, ...

Agatsuma, S. et al., Davilas, A. et al., Dou, L. et al.

L. Dou, N. Jourde-Chiche, V. Faure, C. Cerini, Y. Berland, F. Dignat-George, P. Brunet,

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Disease relevance of INDICAN

The content of indoxyl-beta-D-glucuronide, which has been found in patients' plasma as a new indicator of renal failure, logarithmically correlated with that of 3-indoxyl sulfate (indican) in the plasma of hemodialysis patients, showing another weak correlation with beta(2)-microglobulin content [1].

High impact information on INDICAN

The competitive binding of diflunisal and three well-known uraemic toxins (3-indoxyl sulfate, indole-3-acetic acid and hippuric acid) to bovine serum albumin (BSA), human serum albumin (HSA) and human plasma was studied by direct potentiometry [2].
Indoxyl-beta-D-glucuronide and 3-indoxyl sulfate in plasma of hemodialysis patients [1].

Associations of INDICAN with other chemical compounds

Indoxyl sulfate strongly decreased the levels of glutathione, one of the most active antioxidant systems of the cell [3].

References

Indoxyl-beta-D-glucuronide and 3-indoxyl sulfate in plasma of hemodialysis patients. Agatsuma, S., Sekino, H., Watanabe, H. Clin. Nephrol. (1996) [Pubmed]
In-vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion-probe technique. Davilas, A., Koupparis, M., Macheras, P., Valsami, G. J. Pharm. Pharmacol. (2006) [Pubmed]
The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. Dou, L., Jourde-Chiche, N., Faure, V., Cerini, C., Berland, Y., Dignat-George, F., Brunet, P. J. Thromb. Haemost. (2007) [Pubmed]

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