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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Potentiometry

  • Reaction microcalorimetry and potentiometry have been used to define the thermodynamics of assembly of Escherichia coli aspartate transcarbamoylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC from its catalytic and regulatory subunits and the linkage between assembly and proton binding [1].
  • 1. The b-type haem centres of the three (alpha, beta and gamma) subunit nitrate reductase from Paracoccus denitrificans have been analysed by redox potentiometry [2].

High impact information on Potentiometry

  • The formation of the reactive platinum aquated species was first analyzed by potentiometry using a chloride-specific electrode [3].
  • The room temperature potentiometry of xanthine oxidase. pH-dependent redox behavior of the flavin, molybdenum, and iron-sulfur centers [4].
  • Accordingly, in the present study the acidity constants of catechin and taxifolin, as well as the formation constants of the corresponding copper (II) complexes, were investigated by potentiometry and/or spectrophotometry [5].
  • A second part is dedicated to three useful methods to study liposome/water partitioning, namely potentiometry, equilibrium dialysis, and (1)H-NMR relaxation rates [6].
  • Complexation of the lanthanides Eu(3+), Gd(3+), and Tb(3+) with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota) has been studied in solution by using potentiometry, luminescence spectrometry, and EXAFS [7].

Biological context of Potentiometry


Anatomical context of Potentiometry


Associations of Potentiometry with chemical compounds

  • The protonation constants of the EPTPA-bz-NO(2) (5-) and DPTPA(5-) ligands and the stability constants of their complexes with Gd(III), Zn(II), Cu(II) and Ca(II) were determined by pH potentiometry [14].
  • At pH 7 and 25 degrees C, the midpoint potential for the FAD/FADH2 couple was determined by c.d. potentiometry to be -280 +/- 10 mV (n = 2) [15].
  • The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n-octanol/water and 1,2-dichloroethane/water systems in order to complement our understanding of the lipophilicity of neutral and ionized acids and to clarify the solvation mechanisms responsible for their partition [16].
  • Oxidation-reduction midpoint potentials for flavin, heme, and molybdenum-pterin prosthetic groups of assimilatory nitrate reductase (NR) from Chlorella vulgaris were measured at room temperature by using CD and EPR potentiometry [17].
  • Interferences with potentiometry of CO2 in the Ektachem 400 Analyzer [18].

Gene context of Potentiometry

  • The FAD/NADPH- and FMN-binding domains of NR1 have been expressed and purified and their redox properties studied by stopped-flow and steady-state kinetic methods, and by potentiometry [19].
  • At the beginning and end of the session, NaDI and NaBI were measured in quadruplicate by means of a Nova-1 device (Direct Potentiometry, Pabisch Instruments) [20].
  • Accordingly, formation equilibria of DTT complexes with lead(II) have been investigated under physiological conditions (37 degrees C, NaCl, 0.15 mol. dm-3 using glass electrode potentiometry [21].
  • The coordination properties of the peptide Ac-GluLeuAlaLysHisAla-amide, the C-terminal 102-107 fragment of histone H2B towards Cu(II) and Ni(II) ions were studied by means of potentiometry and spectroscopic techniques (UV/Vis, CD, EPR and NMR) [22].
  • For this purpose, copper determination by square wave voltammetry (SWV) and potentiometry (PSA) stripping analysis using Hg electrodes (drop and film, respectively) were carried out [23].

Analytical, diagnostic and therapeutic context of Potentiometry


  1. Thermodynamics of assembly of Escherichia coli aspartate transcarbamoylase. McCarthy, M.P., Allewell, N.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Respiratory nitrate reductase from Paracoccus denitrificans. Evidence for two b-type haems in the gamma subunit and properties of a water-soluble active enzyme containing alpha and beta subunits. Ballard, A.L., Ferguson, S.J. Eur. J. Biochem. (1988) [Pubmed]
  3. Role of ligand exchange processes in the reaction kinetics of the antitumor drug cis-diamminedichloroplatinum(II) with its targets. Segal, E., Le Pecq, J.B. Cancer Res. (1985) [Pubmed]
  4. The room temperature potentiometry of xanthine oxidase. pH-dependent redox behavior of the flavin, molybdenum, and iron-sulfur centers. Porras, A.G., Palmer, G. J. Biol. Chem. (1982) [Pubmed]
  5. Structure-property studies on the antioxidant activity of flavonoids present in diet. Teixeira, S., Siquet, C., Alves, C., Boal, I., Marques, M.P., Borges, F., Lima, J.L., Reis, S. Free Radic. Biol. Med. (2005) [Pubmed]
  6. Liposome/water lipophilicity: methods, information content, and pharmaceutical applications. van Balen, G.P., Martinet, C.M., Caron, G., Bouchard, G., Reist, M., Carrupt, P.A., Fruttero, R., Gasco, A., Testa, B. Medicinal research reviews. (2004) [Pubmed]
  7. Complexing mechanism of the lanthanide cations Eu(3+), Gd(3+), and Tb(3+) with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota)-characterization of three successive complexing phases: study of the thermodynamic and structural properties of the complexes by potentiometry, luminescence spectroscopy, and EXAFS. Moreau, J., Guillon, E., Pierrard, J.C., Rimbault, J., Port, M., Aplincourt, M. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  8. Active site of dopamine beta-hydroxylase. Comparison of enzyme derivatives containing four and eight copper atoms per tetramer using potentiometry and EPR spectroscopy. Blackburn, N.J., Concannon, M., Shahiyan, S.K., Mabbs, F.E., Collison, D. Biochemistry (1988) [Pubmed]
  9. Lipase assay in duodenal juice using a conductimetric method. Ballot, C., Favre-Bonvin, G., Wallach, J.M. Clin. Chim. Acta (1984) [Pubmed]
  10. Chemiluminescent reactions in the Belousov-Zhabotinskii oscillating system. Zhuravlev, A.I., Trainin, V.M. J. Biolumin. Chemilumin. (1990) [Pubmed]
  11. Ionophore properties of monensin derivatives studied on human erythrocytes by 23Na NMR and K+ and H+ potentiometry: relationship with antimicrobial and antimalarial activities. Rochdi, M., Delort, A.M., Guyot, J., Sancelme, M., Gibot, S., Gourcy, J.G., Dauphin, G., Gumila, C., Vial, H., Jeminet, G. J. Med. Chem. (1996) [Pubmed]
  12. Comparison of the predicted in vivo behaviour of the Sn(II)-APDDMP complex and the results as studied in a rodent model. Zeevaart, J.R., Jansen, D.R., Botelho, M.F., Abrunhosa, A., Gomes, C., Metello, L., Kolar, Z.I., Krijger, G.C., Louw, W.K., Dormehl, I.C. J. Inorg. Biochem. (2004) [Pubmed]
  13. Calcium-induced condensation-reorganization phenomena in multilamellar vesicles of phosphatidic acid. pH potentiometric and 31P-NMR, Raman and ESR spectroscopic studies. Boughriet, A., Ladjadj, M., Bicknell-Brown, E. Biochim. Biophys. Acta (1988) [Pubmed]
  14. GdIII complexes with fast water exchange and high thermodynamic stability: potential building blocks for high-relaxivity MRI contrast agents. Laus, S., Ruloff, R., Tóth, E., Merbach, A.E. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  15. Oxidation--reduction midpoint potentials of the flavin, haem and Mo-pterin centres in spinach (Spinacia oleracea L.) nitrate reductase. Kay, C.J., Barber, M.J., Notton, B.A., Solomonson, L.P. Biochem. J. (1989) [Pubmed]
  16. Lipophilicity and solvation of anionic drugs. Bouchard, G., Carrupt, P.A., Testa, B., Gobry, V., Girault, H.H. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  17. Circular dichroism and potentiometry of FAD, heme and Mo-pterin prosthetic groups of assimilatory nitrate reductase. Kay, C.J., Barber, M.J., Solomonson, L.P. Biochemistry (1988) [Pubmed]
  18. Interferences with potentiometry of CO2 in the Ektachem 400 Analyzer. Steelman, M., Smith, C.H., Menon, A., Thach, B.T., Hillman, R.E., Landt, M. Clin. Chem. (1984) [Pubmed]
  19. Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1. Finn, R.D., Basran, J., Roitel, O., Wolf, C.R., Munro, A.W., Paine, M.J., Scrutton, N.S. Eur. J. Biochem. (2003) [Pubmed]
  20. Determining the adequacy of sodium balance in hemodialysis using a kinetic model. Di Filippo, S., Corti, M., Andrulli, S., Manzoni, C., Locatelli, F. Blood Purif. (1996) [Pubmed]
  21. Lead (II)-dithiothreitol equilibria and their potential influence on lead inhibition of 5-aminolevulinic acid dehydratase in in vitro assays. Gnonlonfoun, N., Filella, M., Berthon, G. J. Inorg. Biochem. (1991) [Pubmed]
  22. Coordination properties of Cu(II) and Ni(II) ions towards the C-terminal peptide fragment -ELAKHA- of histone H2B. Karavelas, T., Mylonas, M., Malandrinos, G., Plakatouras, J.C., Hadjiliadis, N., Mlynarz, P., Kozlowski, H. J. Inorg. Biochem. (2005) [Pubmed]
  23. Electroanalytical determination and fractionation of copper in wine. Sánchez Misiego, A., García-Moncó Carra, R.M., Ambel Carracedo, M.P., Guerra Sánchez-Simón, M.T. J. Agric. Food Chem. (2004) [Pubmed]
  24. Oxidation-reduction potentials of flavin and Mo-pterin centers in assimilatory nitrate reductase: variation with pH. Kay, C.J., Solomonson, L.P., Barber, M.J. Biochemistry (1990) [Pubmed]
  25. Raman spectroscopy of DNA-metal complexes. II. The thermal denaturation of DNA in the presence of Sr2+, Ba2+, Mg2+, Ca2+, Mn2+, Co2+, Ni2+, and Cd2+. Duguid, J.G., Bloomfield, V.A., Benevides, J.M., Thomas, G.J. Biophys. J. (1995) [Pubmed]
  26. Solution chemistry of uranyl ion with iminodiacetate and oxydiacetate: A combined NMR/EXAFS and potentiometry/calorimetry study. Jiang, J., Renshaw, J.C., Sarsfield, M.J., Livens, F.R., Collison, D., Charnock, J.M., Eccles, H. Inorganic chemistry. (2003) [Pubmed]
  27. Serum fluoride levels in a group of Egyptian infants and children from Cairo city. Hossny, E., Reda, S., Marzouk, S., Diab, D., Fahmy, H. Arch. Environ. Health (2003) [Pubmed]
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