Disease relevance of Diisopropylidene acetone

• We have found that depletion of cellular GSH by the addition of phoron, a substrate of glutathione transferase, and buthionine sulfoximine (BSO), an inhibitor of gamma-glutamyl transpeptidase, significantly enhanced DA toxicity [1].

High impact information on Diisopropylidene acetone

• Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo [2].
• The rats were treated with buthionine-sulfoximine, nitrofurantoin (NF) or phorone (Ph), which cause liver oxidative stress with different mechanisms [3].
• After rats were injected with the reduced glutathione (GSH) depletor phorone (diisopropylidene acetone, 250 mg/kg, i.p.), there was a significant increase in microsomal glutathione S-transferase activity in the liver [4].
• Ornithine decarboxylase induction and polyamine biosynthesis by phorone (diisopropylidene acetone), a glutathione depletor, in rats [5].
• Effects of phorone (diisopropylidene acetone), a glutathione (GSH) depletor, on hepatic enzymes involved in drug and heme metabolism in rats: evidence that phorone is a potent inducer of heme oxygenase [6].

Biological context of Diisopropylidene acetone

• Using phorone (diisopropylidene acetone), which proved to be the most potent GSH-depletor, the time- and dose-dependence of the GSH-depletion and the consequent lipid peroxidation was studied [7].

References