The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Mgst1  -  microsomal glutathione S-transferase 1

Rattus norvegicus

Synonyms: Gst12, Microsomal GST-1, Microsomal GST-I, Microsomal glutathione S-transferase 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mgst1


High impact information on Mgst1


Biological context of Mgst1


Anatomical context of Mgst1


Associations of Mgst1 with chemical compounds


Other interactions of Mgst1

  • The cytosolic GST activity was higher in p.v. cells, but the microsomal GST and cytosolic GR were found to be evenly distributed in the acinus [14].
  • The highest increases were seen with microsomal GST (70%), GPX (75%) and cytosolic EH (75%) [15].
  • The most pronounced effects were seen in cytosolic QR (2.2-fold increase), pUGT (95% reduction), pSULT (75% reduction), mitochondrial catalase (75% reduction), microsomal EH (70% reduction) and microsomal GST (55% reduction) [15].
  • While Col IV alpha6 and RpL41 are known to be involved in cellular proliferation, mGST 1 and 7-DHCR are essential for normal Leydig cell steroidogenesis [16].
  • The injection of glucagon resulted, at the same time, in a 43% drop in the hepatic cytosolic GST, without affecting the microsomal GST [17].

Analytical, diagnostic and therapeutic context of Mgst1


  1. Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes. Gunasena, G.H., Kanz, M.F. Journal of toxicology and environmental health. (1997) [Pubmed]
  2. Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells. Yoshimoto, T., Soberman, R.J., Lewis, R.A., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Glutathione S-transferase isoenzymes in rat brain neurons and glia. Johnson, J.A., el Barbary, A., Kornguth, S.E., Brugge, J.F., Siegel, F.L. J. Neurosci. (1993) [Pubmed]
  4. Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite. Ji, Y., Neverova, I., Van Eyk, J.E., Bennett, B.M. J. Biol. Chem. (2006) [Pubmed]
  5. Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. Aniya, Y., Anders, M.W. J. Biol. Chem. (1989) [Pubmed]
  6. Activation of microsomal glutathione s-transferase by peroxynitrite. Ji, Y., Bennett, B.M. Mol. Pharmacol. (2003) [Pubmed]
  7. Regulation of microsomal and cytosolic glutathione S-transferase activities by S-nitrosylation. Ji, Y., Toader, V., Bennett, B.M. Biochem. Pharmacol. (2002) [Pubmed]
  8. Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system. Fetissov, S.O., Schröder, O., Jakobsson, P.J., Samuelsson, B., Haeggström, J.Z., Hökfelt, T. Neuroscience (2002) [Pubmed]
  9. Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes. Onderwater, R.C., Commandeur, J.N., Menge, W.M., Vermeulen, N.P. Chem. Res. Toxicol. (1999) [Pubmed]
  10. Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene. Hargus, S.J., Fitzsimmons, M.E., Aniya, Y., Anders, M.W. Biochemistry (1991) [Pubmed]
  11. Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase. Ji, Y., Akerboom, T.P., Sies, H. Biochem. J. (1996) [Pubmed]
  12. Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Schröder, O., Sjöström, M., Qiu, H., Jakobsson, P.J., Haeggström, J.Z. Cell. Mol. Life Sci. (2005) [Pubmed]
  13. Studies of endogenous inhibitors of microsomal glutathione S-transferase. Boyer, T.D., Zakim, D., Vessey, D.A. Biochem. J. (1982) [Pubmed]
  14. Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes. Kera, Y., Sippel, H.W., Penttilä, K.E., Lindros, K.O. Biochem. Pharmacol. (1987) [Pubmed]
  15. Hypophysectomy and/or peroxisome proliferators strongly influence the levels of phase II xenobiotic metabolizing enzymes in rat testis. Mehrotra, K., Morgenstern, R., Ahlberg, M.B., Georgellis, A. Chem. Biol. Interact. (1999) [Pubmed]
  16. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan, M., Yashwanth, R., Jagannadha Rao, A. Mol. Cell. Endocrinol. (2004) [Pubmed]
  17. Acute regulation of hepatic glutathione S-transferase by insulin and glucagon. Carrillo, M.C., Monti, J.A., Favre, C., Carnovale, C.E. Toxicol. Lett. (1995) [Pubmed]
  18. Identification of an N-acetylated microsomal glutathione S-transferase by mass spectrometry. Shore, L.J., Odell, G.B., Fenselau, C. Biochem. Pharmacol. (1995) [Pubmed]
  19. Activation of microsomal glutathione S-transferase in tert-butyl hydroperoxide-induced oxidative stress of isolated rat liver. Aniya, Y., Daido, A. Jpn. J. Pharmacol. (1994) [Pubmed]
WikiGenes - Universities