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Mgst1  -  microsomal glutathione S-transferase 1

Rattus norvegicus

Synonyms: Gst12, Microsomal GST-1, Microsomal GST-I, Microsomal glutathione S-transferase 1
 
 
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Disease relevance of Mgst1

 

High impact information on Mgst1

 

Biological context of Mgst1

 

Anatomical context of Mgst1

 

Associations of Mgst1 with chemical compounds

 

Other interactions of Mgst1

  • The cytosolic GST activity was higher in p.v. cells, but the microsomal GST and cytosolic GR were found to be evenly distributed in the acinus [14].
  • The highest increases were seen with microsomal GST (70%), GPX (75%) and cytosolic EH (75%) [15].
  • The most pronounced effects were seen in cytosolic QR (2.2-fold increase), pUGT (95% reduction), pSULT (75% reduction), mitochondrial catalase (75% reduction), microsomal EH (70% reduction) and microsomal GST (55% reduction) [15].
  • While Col IV alpha6 and RpL41 are known to be involved in cellular proliferation, mGST 1 and 7-DHCR are essential for normal Leydig cell steroidogenesis [16].
  • The injection of glucagon resulted, at the same time, in a 43% drop in the hepatic cytosolic GST, without affecting the microsomal GST [17].
 

Analytical, diagnostic and therapeutic context of Mgst1

References

  1. Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes. Gunasena, G.H., Kanz, M.F. Journal of toxicology and environmental health. (1997) [Pubmed]
  2. Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells. Yoshimoto, T., Soberman, R.J., Lewis, R.A., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Glutathione S-transferase isoenzymes in rat brain neurons and glia. Johnson, J.A., el Barbary, A., Kornguth, S.E., Brugge, J.F., Siegel, F.L. J. Neurosci. (1993) [Pubmed]
  4. Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite. Ji, Y., Neverova, I., Van Eyk, J.E., Bennett, B.M. J. Biol. Chem. (2006) [Pubmed]
  5. Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. Aniya, Y., Anders, M.W. J. Biol. Chem. (1989) [Pubmed]
  6. Activation of microsomal glutathione s-transferase by peroxynitrite. Ji, Y., Bennett, B.M. Mol. Pharmacol. (2003) [Pubmed]
  7. Regulation of microsomal and cytosolic glutathione S-transferase activities by S-nitrosylation. Ji, Y., Toader, V., Bennett, B.M. Biochem. Pharmacol. (2002) [Pubmed]
  8. Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system. Fetissov, S.O., Schröder, O., Jakobsson, P.J., Samuelsson, B., Haeggström, J.Z., Hökfelt, T. Neuroscience (2002) [Pubmed]
  9. Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes. Onderwater, R.C., Commandeur, J.N., Menge, W.M., Vermeulen, N.P. Chem. Res. Toxicol. (1999) [Pubmed]
  10. Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene. Hargus, S.J., Fitzsimmons, M.E., Aniya, Y., Anders, M.W. Biochemistry (1991) [Pubmed]
  11. Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase. Ji, Y., Akerboom, T.P., Sies, H. Biochem. J. (1996) [Pubmed]
  12. Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. Schröder, O., Sjöström, M., Qiu, H., Jakobsson, P.J., Haeggström, J.Z. Cell. Mol. Life Sci. (2005) [Pubmed]
  13. Studies of endogenous inhibitors of microsomal glutathione S-transferase. Boyer, T.D., Zakim, D., Vessey, D.A. Biochem. J. (1982) [Pubmed]
  14. Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes. Kera, Y., Sippel, H.W., Penttilä, K.E., Lindros, K.O. Biochem. Pharmacol. (1987) [Pubmed]
  15. Hypophysectomy and/or peroxisome proliferators strongly influence the levels of phase II xenobiotic metabolizing enzymes in rat testis. Mehrotra, K., Morgenstern, R., Ahlberg, M.B., Georgellis, A. Chem. Biol. Interact. (1999) [Pubmed]
  16. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan, M., Yashwanth, R., Jagannadha Rao, A. Mol. Cell. Endocrinol. (2004) [Pubmed]
  17. Acute regulation of hepatic glutathione S-transferase by insulin and glucagon. Carrillo, M.C., Monti, J.A., Favre, C., Carnovale, C.E. Toxicol. Lett. (1995) [Pubmed]
  18. Identification of an N-acetylated microsomal glutathione S-transferase by mass spectrometry. Shore, L.J., Odell, G.B., Fenselau, C. Biochem. Pharmacol. (1995) [Pubmed]
  19. Activation of microsomal glutathione S-transferase in tert-butyl hydroperoxide-induced oxidative stress of isolated rat liver. Aniya, Y., Daido, A. Jpn. J. Pharmacol. (1994) [Pubmed]
 
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