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Chemical Compound Review:

PGF1|A 7-[(1R,2S,3R,5S)-3,5- dihydroxy-2-[(3S)-3...

Synonyms: SureCN7736960, KBioGR_000212, KBioSS_000212, CBiol_001949, AC1L2XYT, ...

Aleem, F.A. et al., Schwab, R. et al., Wong, P.Y. et al., Trebino, C.E. et al., Buhrley, L.E. et al., et al.

Schwab, Eissele, Brückner, Gebhard, Becker,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Prostaglandin f1alpha

The parameters IL-6 and PGF1alpha suggested that the immune trauma immediately after surgery was significantly higher in the group of patients with endoscopic hernia repair than in the group of patients who received a Shouldice repair [1].

High impact information on Prostaglandin f1alpha

The dramatic reduction in [3H]PGE2 formation from mPGES-1-/- macrophages compared with controls resulted in TxB2 and 6-keto PGF1alpha becoming the two most abundant prostaglandins in these samples [2].
A gas chromatograph method has been used for the determination of placental progesterone levels in 14 patients aborted at midtrimester by intra-amniotic instillation of prostaglandin F1alpha, also from a control group (five patients) aborted surgically by dilatation and suction [3].
The synthesis and human FP receptor binding affinity of 13,14-dihydro prostaglandin F1alpha sulfonamides: potential treatments for osteoporosis [4].
The frequency of spontaneous in vitro contractions of seminiferous tubules of the rat appeared to be increased in a dose-dependent manner by prostaglandin F1alpha [5].

Analytical, diagnostic and therapeutic context of Prostaglandin f1alpha

The substrate was rapidly converted to a product, which was isolated and identified as 6,15-diketo prostaglandin F1alpha, (6,15-diketo-PGF1alpha) by thin layer chromatography and gas chromatography-mass spectrometry [6].
Release of prostaglandin F1alpha and F2alpha from superfused platelets: quantitative evaluation of the inhibitory effects of some aspirin-like drugs [7].
The levels of main urinary metabolite of prostaglandin F1alpha and F2alpha in human subjects measured by radioimmunoassay [8].

References

Systemic inflammatory response after endoscopic (TEP) vs Shouldice groin hernia repair. Schwab, R., Eissele, S., Brückner, U.B., Gebhard, F., Becker, H.P. Hernia : the journal of hernias and abdominal wall surgery. (2004) [Pubmed]
Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. Trebino, C.E., Eskra, J.D., Wachtmann, T.S., Perez, J.R., Carty, T.J., Audoly, L.P. J. Biol. Chem. (2005) [Pubmed]
The effect of prostaglandin F2alpha on the placental progesterone level in midtrimester abortion. Aleem, F.A., Schulman, H., Saldana, L.R., Hung, H.C. Am. J. Obstet. Gynecol. (1975) [Pubmed]
The synthesis and human FP receptor binding affinity of 13,14-dihydro prostaglandin F1alpha sulfonamides: potential treatments for osteoporosis. Wang, Y., Soper, D.L., Dirr, M.J., deLong, M.A., De, B., Wos, J.A. Chem. Pharm. Bull. (2000) [Pubmed]
Contractility of rat testicular seminiferous tubules in vitro: prostaglandin f 1 alpha and indomethacin-1,2. Buhrley, L.E., Ellis, L.C. Prostaglandins (1975) [Pubmed]
Metabolism of prostacyclin in blood vessels. Wong, P.Y., Sun, F.F., McGiff, J.C. J. Biol. Chem. (1978) [Pubmed]
Release of prostaglandin F1alpha and F2alpha from superfused platelets: quantitative evaluation of the inhibitory effects of some aspirin-like drugs. Patrono, C., Ciabattoni, G., Crossi-Belloni, D. Prostaglandins (1975) [Pubmed]
The levels of main urinary metabolite of prostaglandin F1alpha and F2alpha in human subjects measured by radioimmunoassay. Ohki, S., Nishigaki, Y., Imaki, K., Kurono, M., Hirata, F. Prostaglandins (1976) [Pubmed]

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