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Chemical Compound Review

PERINDOPRIL     (2S,3aS,7aS)-1-[(2S)-2- [[(1S)-1...

Synonyms: Coversum, Coversyl, Coverex, Prestarium, ACEON, ...
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Disease relevance of PERINDOPRIL

  • Proteinuria increased in PO patients (+1562 mg/d) but declined in PE patients (-156 mg/d) (P < 0.05) [1].
  • This CDAA model was also used to elucidate the effect of PE on liver fibrosis development [2].
  • The hepatic hydroxyproline, serum fibrosis markers, alpha-smooth muscle actin (alpha-SMA) immunopositive cells in number, and alpha-(III) pro-collagen mRNA expression were significantly suppressed by PE treatment [2].

High impact information on PERINDOPRIL

  • Three groups were studied: control F1B hamsters (C; n = 14); CSH given placebo (PL; n = 11 ); and perindopril-treated CSH (PE; n = 11) [3].
  • RESULTS: The immunohistochemical evaluation revealed that the glutathione S-transferase placental form (GST-P), and gamma-glutamyltransferase (GGT)-positive preneoplastic foci significantly decreased in the livers of the PE-treated groups [2].
  • After 1 month treatment with placebo or P (2 mg/kg/day), rats were anesthetized and arterial pressure, left ventricular end-diastolic pressure, and central venous pressure were measured with a micromanometer [4].
  • Our in vitro study showed that PE significantly suppressed VEGF-induced tubular formation and the migration of endothelial cells (EC), whereas it did not affect the proliferation of EC [5].
  • PE markedly inhibited liver fibrogenesis associated with suppression of Ac-HSC proliferation and TIMP-1 expression via protein kinase-C, which serves as an intracellular signaling pathway [6].

Analytical, diagnostic and therapeutic context of PERINDOPRIL

  • After constriction of the aorta, the rabbits were treated during a 10-week period with either PE (1 mg/kg/day; n = 9) or a placebo (PL; n = 15) [7].
  • In an allograft study, the ACE inhibitor, perindopril (PE) significantly attenuated VEGF-mediated tumor development accompanying the suppression of neovascularization in the tumor at a clinically comparable low dose [8].


  1. Expansion of cortical interstitium is limited by converting enzyme inhibition in type 2 diabetic patients with glomerulosclerosis. The Diabiopsies Group. Cordonnier, D.J., Pinel, N., Barro, C., Maynard, M., Zaoui, P., Halimi, S., Hurault de Ligny, B., Reznic, Y., Simon, D., Bilous, R.W. J. Am. Soc. Nephrol. (1999) [Pubmed]
  2. Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. Yoshiji, H., Yoshii, J., Ikenaka, Y., Noguchi, R., Tsujinoue, H., Nakatani, T., Imazu, H., Yanase, K., Kuriyama, S., Fukui, H. J. Hepatol. (2002) [Pubmed]
  3. Effects of angiotensin converting enzyme inhibition on crossbridge properties of diaphragm in cardiomyopathic hamsters of the dilated bio 53-58 strain. Lecarpentier, Y., Coirault, C., Lerebours, G., Desche, P., Scalbert, E., Lambert, F., Chemla, D. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  4. Prevention of endothelial dysfunction in small and large arteries in a model of chronic heart failure. Effect of angiotensin converting enzyme inhibition. Thuillez, C., Mulder, P., Elfertak, L., Blaysat, G., Compagnon, P., Henry, J.P., Richard, V., Scalbert, E., Desche, P. Am. J. Hypertens. (1995) [Pubmed]
  5. Suppression of renin-angiotensin system attenuates hepatocarcinogenesis via angiogenesis inhibition in rats. Yoshiji, H., Noguchi, R., Kuriyama, S., Yoshii, J., Ikenaka, Y., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Uemura, M., Fukui, H. Anticancer Res. (2005) [Pubmed]
  6. Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor. Yoshiji, H., Kuriyama, S., Fukui, H. Tumour Biol. (2002) [Pubmed]
  7. Impaired skeletal muscle performance in the early stage of cardiac pressure overload in rabbits: beneficial effects of angiotensin-converting enzyme inhibition. Coirault, C., Langeron, O., Lambert, F., Blanc, F.X., Lerebours, G., Claude, N., Riou, B., Chemla, D., Lecarpentier, Y. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  8. Suppression of the renin-angiotensin system attenuates vascular endothelial growth factor-mediated tumor development and angiogenesis in murine hepatocellular carcinoma cells. Yoshiji, H., Yoshii, J., Ikenaka, Y., Noguchi, R., Yanase, K., Tsujinoue, H., Imazu, H., Fukui, H. Int. J. Oncol. (2002) [Pubmed]
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