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Gene Review

Ggt1  -  gamma-glutamyltransferase 1

Rattus norvegicus

Synonyms: GGLUT, GGT 1, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, Ggt, ...
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Disease relevance of Ggt1


Psychiatry related information on Ggt1


High impact information on Ggt1


Chemical compound and disease context of Ggt1


Biological context of Ggt1


Anatomical context of Ggt1


Associations of Ggt1 with chemical compounds


Enzymatic interactions of Ggt1


Regulatory relationships of Ggt1


Other interactions of Ggt1


Analytical, diagnostic and therapeutic context of Ggt1


  1. Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats. Pereira, M.A., Herren-Freund, S.L., Britt, A.L., Khoury, M.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Carcinogenicity of Fusarium moniliforme culture material in rats. Jaskiewicz, K., van Rensburg, S.J., Marasas, W.F., Gelderblom, W.C. J. Natl. Cancer Inst. (1987) [Pubmed]
  3. Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. Cameron, R., Kellen, J., Kolin, A., Malkin, A., Farber, E. Cancer Res. (1978) [Pubmed]
  4. Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. Lash, L.H., Anders, M.W. J. Biol. Chem. (1986) [Pubmed]
  5. Different constructs for the expression of mammalian gamma-glutamyltransferase cDNAs in Escherichia coli and in Saccharomyces cerevisiae. Angele, C., Oster, T., Visvikis, A., Michels, J.M., Wellman, M., Siest, G. Clin. Chem. (1991) [Pubmed]
  6. Hepatic gamma-glutamyltransferase activity: its increase following chronic alcohol consumption and the role of carbohydrates. Teschke, R., Petrides, A.S. Biochem. Pharmacol. (1982) [Pubmed]
  7. gamma-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate. Zhu, S.G., McGeer, E.G., McGeer, P.L. Exp. Neurol. (1990) [Pubmed]
  8. Effect of dietary protein quality on development of aflatoxin B1-induced hepatic preneoplastic lesions. Schulsinger, D.A., Root, M.M., Campbell, T.C. J. Natl. Cancer Inst. (1989) [Pubmed]
  9. Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. Greaves, P., Irisarri, E., Monro, A.M. J. Natl. Cancer Inst. (1986) [Pubmed]
  10. Influence of cell proliferation on initiating activity of pure polychlorinated biphenyls and complex mixtures in resistant hepatocyte in vivo assays for carcinogenicity. Hayes, M.A., Safe, S.H., Armstrong, D., Cameron, R.G. J. Natl. Cancer Inst. (1985) [Pubmed]
  11. Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis. Capouya, E.R., Lindahl, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  12. Ethanol effects in a rat hepatoma cell line: induction of gamma-glutamyltransferase. Barouki, R., Chobert, M.N., Finidori, J., Aggerbeck, M., Nalpas, B., Hanoune, J. Hepatology (1983) [Pubmed]
  13. Relationship between antioxidant systems, intracellular thiols and DNA ploidy in liver of rats during experimental cirrhogenesis. Sanz, N., Díez-Fernández, C., Fernández-Simón, L., Alvarez, A., Cascales, M. Carcinogenesis (1995) [Pubmed]
  14. An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury. Dahm, L.J., Schultze, A.E., Roth, R.A. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  15. Enteral glutamine modulates renal glutamine utilization. Welbourne, T., Mu, X., Evans, S. J. Nutr. (1996) [Pubmed]
  16. The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. Mikkelsen, I.M., Mortensen, B., Laperche, Y., Huseby, N.E. Mol. Cell. Biochem. (2002) [Pubmed]
  17. Radiation-induced upregulation of gamma-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway. Pankiv, S., Møller, S., Bjørkøy, G., Moens, U., Huseby, N.E. Biochim. Biophys. Acta (2006) [Pubmed]
  18. MTrasT24, a metallothionein-ras fusion gene, modulates expression in cultured rat liver cells of two genes associated with in vivo liver cancer. Li, Y.C., Seyama, T., Godwin, A.K., Winokur, T.S., Lebovitz, R.M., Lieberman, M.W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  19. Slow reacting substances (leukotrienes): enzymes involved in their biosynthesis. Morris, H.R., Taylor, G.W., Jones, C.M., Piper, P.J., Samhoun, M.N., Tippins, J.R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  20. Evidence for participation of transglutaminase in receptor-mediated endocytosis. Levitzki, A., Willingham, M., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  21. In vitro measurement of resistance to phalloidin and gamma-glutamyltransferase of carcinogen-induced preneoplastic hepatocytes of rats. Sawada, N., Furukawa, K., Tsukada, H. J. Natl. Cancer Inst. (1982) [Pubmed]
  22. Modulation of N-nitrosodimethylamine kidney tumorigenesis by unilateral hydronephrosis and multiple putrescine administrations. Ohmori, T., Tabei, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  23. Isolation and characterization of endoplasmic reticulum and Golgi apparatus from hepatocyte nodules in male wistar rats. Eriksson, L.C., Torndal, U.B., Andersson, G.N. Cancer Res. (1983) [Pubmed]
  24. gamma-Glutamyltransferase and the inhibition of azo dye-produced neoplasia by concomitant administration of disulfiram. Fiala, S., Trout, E.C., Ostrander, H., Fiala, A.E. J. Natl. Cancer Inst. (1980) [Pubmed]
  25. In vivo induction of gliadin-mediated enterocyte damage in rats by the mannosidase inhibitor, swainsonine: a possible animal model for celiac disease. Köttgen, E., Beiswenger, M., James, L.F., Bauer, C. Gastroenterology (1988) [Pubmed]
  26. Effects of delays in the cell cycle on the induction of preneoplastic and neoplastic lesions in rat liver by 1,2-dimethylhydrazine. Ying, T.S., Enomoto, K., Sarma, D.S., Farber, E. Cancer Res. (1982) [Pubmed]
  27. Rat renal gamma-glutamyltransferase activity: a reaction of glutamine synthetase. Bregar, F.W., Hughey, R.P., Curthoys, N.P. Can. J. Biochem. (1981) [Pubmed]
  28. Gamma-glutamyltransferase activity in mammary gland of pregnant rats and its regulation by ovarian hormones, prolactin and placental lactogen. Bussmann, L.E., Deis, R.P. Biochem. J. (1984) [Pubmed]
  29. Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene. Nakae, D., Denda, A., Kobayashi, Y., Akai, H., Kishida, H., Tsujiuchi, T., Konishi, Y., Suzuki, T., Muramatsu, M. Jpn. J. Cancer Res. (1998) [Pubmed]
  30. Turnover of hepatic glutathione after acute lindane intoxication. Junqueira, V.B., Barros, S.B., Simizu, K., Fernández, V., Carrión, Y., Pimentel, R., Azzalis, L.A., Videla, L.A. Toxicol. Lett. (1993) [Pubmed]
  31. Effect of H1 and H2 receptor antagonists on the serum activity of gamma-glutamyltransferase during liver regeneration after partial hepatectomy in rats. Kozlowski, V.A., Mattos Filho, T.R. Pharmacology (1995) [Pubmed]
  32. Changes in activities of glutathione peroxidase and glutathione reductase during chemical hepatocarcinogenesis in the rat. Kitahara, A., Yamazaki, T., Ishikawa, T., Camba, E.A., Sato, K. Gann = Gan. (1983) [Pubmed]
  33. Induction of gamma-glutamyltransferase-positive and nonspecific esterase-positive foci in rat liver by partial hepatectomy following single injection of N-nitrosodiethylamine. Hirota, N., Moriyama, S., Yokoyama, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  34. Immunocytochemical localization of gamma-glutamyltransferase in rat kidney with protein A-horseradish peroxidase. Spater, H.W., Poruchynsky, M.S., Quintana, N., Inoue, M., Novikoff, A.B. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  35. Suppression of natural killer and lymphocyte functions associated with carcinogen-induced premalignant hyperplastic nodules in rat liver. Leu, R.W., Norton, T.R., Herriott, M.J., Ringer, D.P., Kearns, R.J. Cancer Res. (1985) [Pubmed]
  36. Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats. Hsu, D.Z., Liu, M.Y. Crit. Care Med. (2002) [Pubmed]
  37. Influence of thyroid hormone administration on hepatic glutathione content and basolateral gamma-glutamyltransferase ectoactivity in the isolated perfused rat liver. Carrion, Y., Fernandez, V., Videla, L.A. Biochem. Pharmacol. (1993) [Pubmed]
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