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Chemical Compound Review:

CCRIS 2062 3-azidopropane-1,2-diol

Synonyms: ACMC-20mu1o, KST-1B8380, AC1Q1UGJ, AR-1B6040, LS-120153, ...

Grúz, P. et al., Juricek, M. et al., Grant, W.F. et al.

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Disease relevance of CCRIS 2062

Mutagenicity of 3-azido-1,2-propanediol and 9-(3-azido-2-hydroxypropyl)-adenine in repair deficient strains of Escherichia coli [1].
AG is at best a weak clastogen and is without effect in inducing chromosomal aberrations and SCEs in human peripheral lymphocytes in vitro [2].
6-Azido-6-deoxy (AZd) derivatives of D-glucose, D-mannose, D-altrose, D-allose, L-idose, D-galactose, D-galactonic acid and D-galactitol, 3-azido-1,2-propanediol (azidoglycerol), 3,1-diazido-2-propanol (diazidoglycerol) and (at much higher doses) 2-azidoethanol were mutagenic in Salmonella typhimurium strains TA100 and TA1535 [3].

High impact information on CCRIS 2062

The mutagenicity of two non-aromatic organic azido compounds, 3-azido-1,2-propanediol (AG) and 9-(3-azido-2-hydroxypropyl)-adenine (AHPA), was studied in E. coli repair deficient strains uvrA6, uvrA6 + umuC36, uvrA6+ umuC122::Tn5, polA1, tagA1+ alkA1, ada and dam3 [1].

References

Mutagenicity of 3-azido-1,2-propanediol and 9-(3-azido-2-hydroxypropyl)-adenine in repair deficient strains of Escherichia coli. Grúz, P., Jurícek, M., Zák, P., Velemínský, J. Mutat. Res. (1993) [Pubmed]
Comparative mutagenicity of chemicals selected for test in the International Program on Chemical Safety's collaborative study on plant systems for the detection of environmental mutagens. Grant, W.F., Salamone, M.F. Mutat. Res. (1994) [Pubmed]
Mutagenic activity of 6-azido deoxyhexoses and azido alcohols in Salmonella typhimurium and its inhibition by a structure-similar carbon source in the medium. Juricek, M., Gruz, P., Veleminsky, J., Stanek, J., Kefurt, K., Moravcova, J., Jary, J. Mutat. Res. (1991) [Pubmed]

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