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Chemical Compound Review:

Prolinamide (2S)-pyrrolidine-2-carboxamide

Synonyms: l-prolinamid, L-prolinamide, l-Prolineamide, H-L-PRO-NH2, h-pro-nh2, ...

Ogasawara, T. et al., Matsushita, M. et al., Jacobs, J.W. et al., Smith, L.K. et al.

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Disease relevance of proline

Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia [1].

High impact information on proline

The location of glycine next to the carboxyl terminal prolinamide of calcitonin is consistent with indications that glycine is required for the enzymatic amidation of proline to the prolinamide [2].
The insulin receptor substrate 1 (IRS-1) contains at least 11 sequence motifs that are rich in proline (P), glutamic acid (E), serine (S), and threonine (T), i.e., PEST regions [3].
The effects of thyrotropin-releasing hormone (TRH) and its analog, N-[[(3R,6R)-6-methyl-5-oxo-thiomorpholinyl] carbonyl]-L-histidyl-L- prolinamide tetrahydrate (NS-3, CG3703) on disturbance of memory of a passive avoidance response (PAR) and an escape response in rats were investigated [4].

References

Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. Matsushita, M., Yonemori, F., Ohta, A., Iwata, K. Arzneimittel-Forschung. (1995) [Pubmed]
Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Jacobs, J.W., Goodman, R.H., Chin, W.W., Dee, P.C., Habener, J.F., Bell, N.H., Potts, J.T. Science (1981) [Pubmed]
The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro. Smith, L.K., Bradshaw, M., Croall, D.E., Garner, C.W. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats. Ogasawara, T., Ukai, Y., Tamura, M., Kimura, K. Pharmacol. Biochem. Behav. (1995) [Pubmed]

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