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Chemical Compound Review:

AG-D-35400 (2S)-2-amino-4-[[(1S)-2-(3- bromo-2,5...

Synonyms: CTK4A8949, AC1L3P2T, 114865-64-4, 2-Br-6-(Gsyl)HQ, 2-Bromo-6-(glutathion-S-yl)hydroquinone, ...

Mertens, J.J. et al., Jeong, J.K. et al., Monks, T.J. et al.

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Disease relevance of 2-Bromo-6-(monoglutathion-S-yl)hydroquinone

In contrast, 2-Br-3-(GSyl)HQ, 2-Br-5-(GSyl)HQ, and 2-Br-6-(GSyl)HQ caused differentially less toxicity than the diglutathionyl conjugate [1].

High impact information on 2-Bromo-6-(monoglutathion-S-yl)hydroquinone

We therefore compared the effects of a physiologically induced (serum and nutrient depletion) and a chemically induced (2-Br-bis-(GSyl)HQ and 2-Br-6-(GSyl)HQ) stress in renal tubular epithelial cells (LLC-PK1) [2].
Moreover, inhibition of poly(ADP-ribose)polymerase with 3-amino-benzamide (10 mM), following exposure of LLC-PK1 cells to 0.5 mM 2-bromo-6-(glutathion-S-yl)hydroquinone or 2-bromo-(diglutathion-S-yl)hydroquinone, decreased cytotoxicity, indicating that DNA repair processes, activated in response to DNA damage, exacerbate toxicity [3].
A decrease in the cytotoxicity caused by 2-bromo-6-(glutathion-S-yl)hydroquinone and 2-bromo-(diglutathion-S-yl)hydroquinone was observed when cells were incubated with catalase or pretreated with deferoxamine (10 mM) [3].

Biological context of 2-Bromo-6-(monoglutathion-S-yl)hydroquinone

Exposure of renal proximal tubular epithelial cells (LLC-PK1) to the nephrotoxicants 2-bromo-6-(glutathion-S-yl)hydroquinone, 2-bromo-3-(glutathion-S-yl)-hydroquinone, and 2-bromo-(diglutathion-S-yl)hydroquinone caused DNA fragmentation and cytotoxicity [3].

References

2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants. Monks, T.J., Highet, R.J., Lau, S.S. Mol. Pharmacol. (1988) [Pubmed]
The response of renal tubular epithelial cells to physiologically and chemically induced growth arrest. Jeong, J.K., Huang, Q., Lau, S.S., Monks, T.J. J. Biol. Chem. (1997) [Pubmed]
Reactive oxygen species and DNA damage in 2-bromo-(glutathion-S-yl) hydroquinone-mediated cytotoxicity. Mertens, J.J., Gibson, N.W., Lau, S.S., Monks, T.J. Arch. Biochem. Biophys. (1995) [Pubmed]

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