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Chemical Compound Review:

CHEBI:41351 (2R,3R,4R)-2,3,4-trihydroxy- 5-phosphonooxy...

Synonyms: AC1L3U6V, 2-Cabp, 27442-42-8, 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, 2-carboxyarabinitol 1,5-biphosphate, ...

Smrcka, A.V. et al., Mogel, S.N. et al., Yokota, A. et al., Mizohata, E. et al., Choe, H.W. et al.

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Disease relevance of D-Ribonic acid, 2-C-((phosphonooxy)methyl)-, 5-(dihydrogen phosphate)

The large subunit (L) of ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) from Synechococcus PCC 6301 was expressed in Escherichia coli, purified as the octamer L8, and analyzed for its ability to tightly bind the transition state analog, 2-carboxyarabinitol 1,5-bisphosphate (CABP) [1].

High impact information on D-Ribonic acid, 2-C-((phosphonooxy)methyl)-, 5-(dihydrogen phosphate)

Crystal structure of activated ribulose-1,5-bisphosphate carboxylase/oxygenase from green alga Chlamydomonas reinhardtii complexed with 2-carboxyarabinitol-1,5-bisphosphate [2].
The luminescence is ribulose 1,5-bisphosphate (RuBP) and O2-dependent and is inhibited by 2-carboxyarabinitol 1,5-bisphosphate and high concentrations of bicarbonate; it is therefore ascribed to the RuBP oxygenase activity [3].
The modification of these residues was strongly suppressed in the enzyme form that had undergone hysteretic conformational change after binding 2-carboxyarabinitol 1,5-bisphosphate at its catalytic sites [4].

Analytical, diagnostic and therapeutic context of D-Ribonic acid, 2-C-((phosphonooxy)methyl)-, 5-(dihydrogen phosphate)

Crystallization is sensitive to variation in pH and to the addition of the transition state analog, 2-carboxyarabinitol-1,5-bisphosphate [5].

References

Modulation of the tight binding of carboxyarabinitol 1,5-bisphosphate to the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase. Smrcka, A.V., Bohnert, H.J., Jensen, R.G. Arch. Biochem. Biophys. (1991) [Pubmed]
Crystal structure of activated ribulose-1,5-bisphosphate carboxylase/oxygenase from green alga Chlamydomonas reinhardtii complexed with 2-carboxyarabinitol-1,5-bisphosphate. Mizohata, E., Matsumura, H., Okano, Y., Kumei, M., Takuma, H., Onodera, J., Kato, K., Shibata, N., Inoue, T., Yokota, A., Kai, Y. J. Mol. Biol. (2002) [Pubmed]
Chemiluminescence of the Mn2(+)-activated ribulose-1,5-bisphosphate oxygenase reaction: evidence for singlet oxygen production. Mogel, S.N., McFadden, B.A. Biochemistry (1990) [Pubmed]
Lysine residues involved in the hysteresis and in the regulatory sites of spinach ribulose 1,5-bisphosphate carboxylase/oxygenase. Yokota, A., Tokai, H. J. Biochem. (1993) [Pubmed]
Crystallization of the activated ternary complex of ribulose-1,5-bisphosphate carboxylase-oxygenase isolated from Rhodospirillum rubrum and from an Escherichia coli clone. Choe, H.W., Jakob, R., Hahn, U., Pal, G.P. J. Mol. Biol. (1985) [Pubmed]

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