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Chemical Compound Review

Ethylisokyanid     isocyanoethane

Synonyms: Isocyanoethane, AG-G-29498, AK-45383, LS-52267, BBL021349, ...
 
 
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High impact information on isocyanoethane

  • In contrast, no significant change in the ethylisocyanide difference spectra of reduced microsomes is obtained after induction; moreover, the spectra obtained with induced and noninduced cytochrome P-450 are similar to the one shown by hepatic microsomes from polycyclic hydrocarbon-treated rats [1].
  • Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes [2].
  • Ethylisocyanide equilibria of hemoglobins M Iwate, M Boston, M Hyde Park, M Saskatoon, and M Milwaukee-I in half-ferric and fully reduced states [3].
  • A number of criteria including substrate specificity, pattern of benzo(a)pyrene metabolism, sensitivity to inhibitors, substrate binding spectra, ethylisocyanide binding spectra, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and crossed immunoelectrophoresis were used to answer this question [4].
  • The qualitative change in cytochrome P-450 reflected in the ethylisocyanide binding spectrum was also apparent after treatment with methadone, PB, or 3-MC, and the combination of methadone and PB exhibited effects that differed from PB alone [5].
 

Biological context of isocyanoethane

  • The kinetics and equilibria of carbon monoxide and ethylisocyanide binding reported here show a dependence on protein concentration that supports the conclusion that the aggregated hemoglobin has a lower ligand affinity than the dissociated subunits [6].
 

Gene context of isocyanoethane

References

  1. Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration. Capdevila, J., Jakobsson, S.W., Jernström, B., Helia, O., Orrenius, S. Cancer Res. (1975) [Pubmed]
  2. Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes. Kahl, G.F., Kahl, R., Kumaki, K., Nebert, D.W. J. Biol. Chem. (1976) [Pubmed]
  3. Ethylisocyanide equilibria of hemoglobins M Iwate, M Boston, M Hyde Park, M Saskatoon, and M Milwaukee-I in half-ferric and fully reduced states. Nishikura, K., Sugita, Y., Nagai, M., Yoneyama, Y. J. Biol. Chem. (1975) [Pubmed]
  4. Characterization of the microsomal cytochrome P-450 species induced in rat liver by trans-stilbene oxide. Meijer, J., Astrom, A., DePierre, J.W., Guengerich, F.P., Ernster, L. Biochem. Pharmacol. (1982) [Pubmed]
  5. Microsomal spectral properties and narcotic N-demethylase activity in methadone-dependent rats. Spaulding, T.C., Kotake, A.N., Takemori, A.E. Drug Metab. Dispos. (1976) [Pubmed]
  6. Functional consequences of ligand-linked dissociation in hemoglobin from the sea cucumber Molpadia arenicola. Bonaventura, C., Bonaventura, J., Kitto, B., Brunori, M., Antonini, E. Biochim. Biophys. Acta (1976) [Pubmed]
  7. Stimulation of hepatic microsomal metabolism in mice by a mixture of polybrominated biphenyls. Dent, J.G., Roes, U., Netter, K.J., Gibson, J.E. Journal of toxicology and environmental health. (1977) [Pubmed]
 
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