Disease relevance of Methyl isocyanat

• These results demonstrate the genotoxic response of MIC-modified DNA in E. coli [1].
• The results therefore confirm that MIC in its native form or as its unknown metabolites is responsible for the mutagenic activity reported earlier by us in the his tester strains TA100 and TA104 of Salmonella typhimurium (Mutation Res., 204 (1988) 123-129) and not due to its hydrolysis products, MA or DMU [2].
• Questions about the nature of MIC toxicity have been raised by the persistence of multi-systemic symptoms in survivors [3].

High impact information on Methyl isocyanat

• Modification of M13mp9 RF DNA with MIC induced MIC-dose-related, SOS-dependent mutations in the beta-galactosidase locus [1].
• The presence of MIC trimer and a few other identified as well as unidentified tank residue constituents in the blood and viscera further established a close nexus of the products of pyrolysis of MIC in the aerosol inhaled by the victims [4].
• Effect of methyl isocyanate (MIC) on rat erythrocytes [5].
• Animal studies using radio-labeled MIC given by the inhalation route have shown that the radio-label is capable of crossing the lung membranes and being distributed to many organs of the body [3].
• Inhalation toxicity studies of methyl isocyanate (MIC) in rats: Part I--Pulmonary pathology and genotoxicity evaluation [6].

Biological context of Methyl isocyanat

• Inhalation toxicity studies of methyl isocyanate (MIC) in rats: Part III--Studies on biotransformation enzymes [7].

Analytical, diagnostic and therapeutic context of Methyl isocyanat

• In December, 1984, in Bhopal, India, a massive leak of methyl isocyanate (MIC) resulted from operational and equipment malfunctions in a pesticide plant [8].

References