Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL72928 (2R,3R,4S,5R)-2-(6- aminopurin-9-yl)-4...

Synonyms: SureCN969050, AG-G-99004, CHEBI:218275, AC1L3UXV, AC1Q4HHR, ...

Van Aerschot, A. et al., Smee, D.F. et al.

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Disease relevance of AIDS-001240

3'-Fluoro-3'-deoxyadenosine also proved effective in vivo, in inhibiting tail lesion formation in mice inoculated intravenously with vaccinia virus [1].
Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine [2].

High impact information on AIDS-001240

A novel nucleoside analog, 3'-fluoro-3'-deoxyadenosine (3'F3'dAdo), was evaluated for antiviral activity against several arthropod-borne and arenaviruses in Vero cell culture [2].
3'-Fluoro-3'-deoxyadenosine was active against a broad range of viruses, encompassing both DNA viruses [pox (vaccinia)], single-stranded (+) RNA viruses [picorna (polio, Coxsackie B), toga (sindbis, Semliki Forest)] and double-stranded RNA viruses (reo) [1].
In its antiviral activity spectrum 3'-fluoro-3'-deoxyadenosine clearly differed from those adenosine analogues that are known as inhibitors of S-adenosylhomocysteine hydrolase [1].

References

Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine. Van Aerschot, A., Herdewijn, P., Janssen, G., Cools, M., De Clercq, E. Antiviral Res. (1989) [Pubmed]
Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine. Smee, D.F., Morris, J.L., Barnard, D.L., Van Aerschot, A. Antiviral Res. (1992) [Pubmed]

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