Gene Review:
AHCY - adenosylhomocysteinase
Homo sapiens
Synonyms:
Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, SAHH, adoHcyase
- S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. Hershfield, M.S., Krodich, N.M. Science (1978)
- Capillary electrophoresis in diagnosis and monitoring of adenosine deaminase deficiency. Carlucci, F., Tabucchi, A., Aiuti, A., Rosi, F., Floccari, F., Pagani, R., Marinello, E. Clin. Chem. (2003)
- Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis. Gellekink, H., den Heijer, M., Kluijtmans, L.A., Blom, H.J. Eur. J. Hum. Genet. (2004)
- Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism. Kaminska, J.E., Fox, I.H. J. Lab. Clin. Med. (1980)
- Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy. Sacks, S.L., Merigan, T.C., Kaminska, J., Fox, I.H. J. Clin. Invest. (1982)
- Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Migchielsen, A.A., Breuer, M.L., van Roon, M.A., te Riele, H., Zurcher, C., Ossendorp, F., Toutain, S., Hershfield, M.S., Berns, A., Valerio, D. Nat. Genet. (1995)
- Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. Hershfield, M.S., Buckley, R.H., Greenberg, M.L., Melton, A.L., Schiff, R., Hatem, C., Kurtzberg, J., Markert, M.L., Kobayashi, R.H., Kobayashi, A.L. N. Engl. J. Med. (1987)
- The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20. Hershfield, M.S., Francke, U. Science (1982)
- Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase. Ueland, P.M. Pharmacol. Rev. (1982)
- Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation. Hershfield, M.S., Kredich, N.M. Proc. Natl. Acad. Sci. U.S.A. (1980)
- S-adenosylhomocysteine hydrolase inactivation and purine toxicity in cultured human T- and B-lymphoblasts. Young, G.J., Hallam, L.J., Jack, I., Van Der Weyden, M.B. J. Lab. Clin. Med. (1984)
- Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. Cooper, B.J., Key, B., Carter, A., Angel, N.Z., Hart, D.N., Kato, M. J. Biol. Chem. (2006)
- Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20. Mohandas, T., Sparkes, R.S., Suh, E.J., Hershfield, M.S. Hum. Genet. (1984)
- Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY). Arredondo-Vega, F.X., Charlton, J.A., Edwards, Y.H., Hopkinson, D.A., Whitehouse, D.B. Ann. Hum. Genet. (1989)
- Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man. Bissbort, S., Bender, K., Wienker, T.F., Grzeschik, K.H. Hum. Genet. (1983)
- Nucleotide and adenosine metabolism in different cell types of human and rat heart. Kochan, Z., Smolenski, R.T., Yacoub, M.H., Seymour, A.L. J. Mol. Cell. Cardiol. (1994)
- Function of murine adenosine deaminase in the gastrointestinal tract. Xu, P.A., Kellems, R.E. Biochem. Biophys. Res. Commun. (2000)
- S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Baric, I., Fumic, K., Glenn, B., Cuk, M., Schulze, A., Finkelstein, J.D., James, S.J., Mejaski-Bosnjak, V., Pazanin, L., Pogribny, I.P., Rados, M., Sarnavka, V., Scukanec-Spoljar, M., Allen, R.H., Stabler, S., Uzelac, L., Vugrek, O., Wagner, C., Zeisel, S., Mudd, S.H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions. Yang, X., Hu, Y., Yin, D.H., Turner, M.A., Wang, M., Borchardt, R.T., Howell, P.L., Kuczera, K., Schowen, R.L. Biochemistry (2003)
- Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients. Hershfield, M.S. J. Clin. Invest. (1981)
- S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase. Montero, C., Smolenski, R.T., Duley, J.A., Simmonds, H.A. Biochem. Pharmacol. (1990)
- Linkage relations of JK, CO, KEL and IGK with each other and with AHCY. Bender, K., Bissbort, S., Crone, H., Senff, H., Steiert, A., Neumann, H., Koch, M., Nagel, M., Wienker, T.F. Hum. Hered. (1988)
- Differential distribution of purine metabolizing enzymes between glia and neurons. Ceballos, G., Tuttle, J.B., Rubio, R. J. Neurochem. (1994)
- 5'-deoxy-5'-methylthioadenosine phosphorylase--IV. Biological activity of 2-fluoroadenine-substituted 5'-deoxy-5'-methylthioadenosine analogs. Savarese, T.M., Cannistra, A.J., Parks, R.E., Secrist, J.A., Shortnacy, A.T., Montgomery, J.A. Biochem. Pharmacol. (1987)
- S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing. Bozzi, A., Furciniti-La Chiusa, B., Strom, R., Crifò, C. Clin. Chim. Acta (1990)
- Chemical modification and site-directed mutagenesis of cysteine residues in human placental S-adenosylhomocysteine hydrolase. Yuan, C.S., Ault-Riché, D.B., Borchardt, R.T. J. Biol. Chem. (1996)
- S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy. Wolfe, M.S., Borchardt, R.T. J. Med. Chem. (1991)
- S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. Hershfield, M.S., Aiyar, V.N., Premakumar, R., Small, W.C. Biochem. J. (1985)
- S-Adenosyl methionine/S-adenosyl-L-homocysteine ratio determination by capillary electrophoresis employed as a monitoring tool for the antiviral effectiveness of adenosine analogs. Sbrana, E., Bramanti, E., Spinetti, M.C., Raspi, G. Electrophoresis (2004)