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Chemical Compound Review:

Methacyl 6-methyl-1H-pyrimidine-2,4- dione

Synonyms: Metacyl, Pseudothymine, PubChem20755, ARONIS23909, SureCN60308, ...

Charitha, L. et al., Nguyen, N.A. et al., Morgenstern, E. et al., Anikienko, K.A. et al., Gorshkova, O.V. et al.

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Disease relevance of Metacil

AWD 23-15 (6-Methyl-1,2,3,4-tetrahydro-pyrimidin-2,4 dion) which is known to improve learning and memory processes in laboratory animals, was investigated in several hypoxia models [1].

High impact information on Metacil

These data indicated that the 6-methyl nucleosides underwent partial or complete hydrolysis to yield their corresponding sugars and 6-methylcytosine, which then deaminated to 6-methyluracil [2].
In view of this, the oxidation of pyrimidine bases viz., thymine, uracil, cytosine, 5-bromouracil, 6-methyluracil and 1,3-dimethyluracil by t-BuO* radicals in aqueous solution at pH 7.5 has been carried out [3].
The effect of C-547, a tetraalkylammonium derivative of 6-methyluracil, a novel highly selective acetylcholinesterase inhibitor, on frog neuromuscular junction was studied [4].
Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals [5].

References

Antihypoxic effects of AWD 23-15 in mice and rats. Morgenstern, E., Rostock, A., Siegemund, C., Göres, E., Bartsch, R., Wustmann, C., Fischer, H.D. Biomed. Biochim. Acta (1989) [Pubmed]
Substituent effects on degradation rates and pathways of cytosine nucleosides. Nguyen, N.A., Notari, R.E. Journal of pharmaceutical sciences. (1989) [Pubmed]
Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals. Charitha, L., Adinarayana, M. Indian J. Biochem. Biophys. (2005) [Pubmed]
Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction. Gorshkova, O.V., Zobov, V.V., Bukharaeva, E.A., Nikol'skii, E.E., Akamsin, V.D., Galyametdinova, I.V., Reznik, V.S. Bull. Exp. Biol. Med. (2001) [Pubmed]
Tetraalkylammonium derivatives of 6-methyluracil, a new class of cholinesterase inhibitors: characteristics of interaction with cholinesterases from different groups of animals. Anikienko, K.A., Bychikhin, E.A., Kurochkin, V.K., Reznik, V.S., Akamsin, V.D., Galyametdinova, I.V. Dokl. Biochem. Biophys. (2001) [Pubmed]

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